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ERK2 抗体

MAPK1 适用: 人 WB, ELISA, IHC, ICC 宿主: 小鼠 Monoclonal 4C11 unconjugated
产品编号 ABIN1724654
发货至: 中国
  • 抗原 See all ERK2 (MAPK1) 抗体
    ERK2 (MAPK1) (Mitogen-Activated Protein Kinase 1 (MAPK1))
    适用
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    宿主
    • 83
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    小鼠
    克隆类型
    • 79
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    单克隆
    标记
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    This ERK2 antibody is un-conjugated
    应用范围
    • 88
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    • 9
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    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC)
    原理
    ERK2 Antibody
    纯化方法
    Purified antibody
    免疫原
    Purified recombinant fragment of human ERK2 expressed in E. Coli.
    克隆位点
    4C11
    亚型
    IgG2a
    Top Product
    Discover our top product MAPK1 Primary Antibody
  • 应用备注

    ELISA: 1/10000

    ICC: 1/200 - 1/1000

    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified antibody in PBS containing 0.03 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Whitehurst, Robinson, Moore, Cobb: "The death effector domain protein PEA-15 prevents nuclear entry of ERK2 by inhibiting required interactions." in: The Journal of biological chemistry, Vol. 279, Issue 13, pp. 12840-7, (2004) (PubMed).

    Hatano, Mori, Oh-hora, Kosugi, Fujikawa, Nakai, Niwa, Miyazaki, Hamaoka, Ogata: "Essential role for ERK2 mitogen-activated protein kinase in placental development." in: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 8, Issue 11, pp. 847-56, (2003) (PubMed).

  • 抗原
    ERK2 (MAPK1) (Mitogen-Activated Protein Kinase 1 (MAPK1))
    别名
    ERK2 (MAPK1 产品)
    背景

    Description: ERK2 (also designated extracellular-signal-related kinase 2 or mitogen-activated protein kinase 1), with 360-amino acid protein (about 40 kDa), belongs to the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of ERK2 requires its phosphorylation by upstream kinases. ERK2 is located in the cytoplasm of resting cells and translocates into the nucleus upon extracellular stimuli by active transport of a dimer. ERK2 is essential for placental development and ERK2 in the trophoblast compartment may be indispensable for the vascularization of the labyrinth.

    Aliases: ERK, p38, p40, p41, ERT1, MAPK2, PRKM1, P42MAPK, p41mapk, MAPK1

    分子量
    41kDa
    基因ID
    5594
    HGNC
    5594
    UniProt
    P28482
    途径
    MAPK Pathway, RTK signaling, Apoptosis, Interferon-gamma Pathway, Fc-epsilon Receptor Signaling Pathway, Response to Growth Hormone Stimulus, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Protein targeting to Nucleus, Toll-Like Receptors Cascades, Monocarboxylic Acid Catabolic Process, Autophagy, G-protein mediated Events, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, VEGFR1 Specific Signals, BCR Signaling, S100 Proteins
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