Spartan 抗体 (AA 31-130)
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- 抗原 See all Spartan (C1orf124) products
- Spartan (C1orf124) (Chromosome 1 Open Reading Frame 124 (C1orf124))
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抗原表位
- AA 31-130
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Spartan antibody is un-conjugated
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应用范围
- ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)
- 预测反应
- Human,Mouse,Rat,Dog,Cow,Pig,Horse,Rabbit
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human C1orf124
- 亚型
- IgG
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anti-Chromosome 1 Open Reading Frame 124 (C1orf124) antibody
C1orf124 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Chromosome 1 Open Reading Frame 124 (C1orf124) (AA 1-239) antibodyC1orf124 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Chromosome 1 Open Reading Frame 124 (C1orf124) (AA 1-489) antibodyC1orf124 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Chromosome 1 Open Reading Frame 124 (C1orf124) (AA 186-235) antibodyC1orf124 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Chromosome 1 Open Reading Frame 124 (C1orf124) (AA 1-240) antibodyC1orf124 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- 有效期
- 12 months
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- 抗原
- Spartan (C1orf124) (Chromosome 1 Open Reading Frame 124 (C1orf124))
- 别名
- C1orf124 (C1orf124 产品)
- 别名
- Spartan antibody, c1orf124 antibody, C1orf124 antibody, DDDL1880 antibody, DVC1 antibody, PRO4323 antibody, dJ876B10.3 antibody, C28H1orf124 antibody, SprT-like N-terminal domain antibody, sprtn antibody, SPRTN antibody
- 背景
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Synonyms: C1orf124, CA124_HUMAN, Chromosome 1 open reading frame 124, DDDL1880, dJ876B10.3, PRO4323, RP5-876B10.3, Zinc finger RAD18 domain-containing protein C1orf124, SPRTN, SprT-like domain-containing protein Spartan, DVC1, DNA damage protein targeting VCP.
Background: Regulator of UV-induced DNA damage response: acts as a 'reader' of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis (TLS). Recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. Facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. Acts as a regulator of TLS by recruiting VCP/p97 to sites of DNA damage, possibly leading to extraction of DNA polymerase eta (POLH) by VCP/p97 to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage.
- 基因ID
- 83932
- UniProt
- Q9H040
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