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HFE 抗体 (AA 262-348)

Name: HFE 抗体 (AA 262-348)
SKU: ABIN1714561
Availability: OutOfStock

HFE 适用: 人 WB, ELISA, FACS, IF (cc), IF (p), IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated

Iron export machinery-related hephaestin (HEPH) and the hemochromatosis gene (HFE) related to systemic iron loading are elevated at the mRNA level but not on the protein level in tumor-initiating cells (TICs)Expression of the HEPH gene at the mRNA level in breast non-malignant cell line MCF10A, in TICs derived from breast cancer cell lines MCF-7, BT-474, T-47D and ZR-75-30 as well as from prostate cancer cell lines DU-145 and LNCaP has been determined (A) together with protein levels in the MCF-7 cell line (CTRL) and MCF-7 derived spheres (SPH) (B). (HFE 抗体 (AA 262-348))

1 image

(1 reference)

产品编号 ABIN1714561

发货至: 中国

Datasheet as PDF

抗原 See all HFE 抗体

HFE (Hemochromatosis (HFE))
抗原表位
15

5

4

3

3

1

1

1

1

1

1

1

1

1

1
AA 262-348
适用
53

8

7

5

5

2

2

1

1

1

1
人
宿主
48

6
兔
Compatible Secondaries
克隆类型
49

5
多克隆
标记
26

3

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This HFE antibody is un-conjugated
应用范围
41

18

13

12

12

6

4

4

2

2

1

1
Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

交叉反应

人

预测反应

Mouse,Rat,Dog,Cow,Sheep,Horse

纯化方法

Purified by Protein A.

免疫原

KLH conjugated synthetic peptide derived from human HFE/Hemochromatosis

亚型

IgG

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anti-Hemochromatosis (HFE) (AA 115-205) antibody
HFE 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1G12 unconjugated

anti-Hemochromatosis (HFE) antibody
HFE 适用: 人 ELISA, ICC 宿主: 小鼠 Monoclonal 3F1 unconjugated

anti-Hemochromatosis (HFE) (AA 1-348) antibody
HFE 适用: 人 WB, FACS 宿主: 小鼠 Polyclonal unconjugated

anti-Hemochromatosis (HFE) (Internal Region) antibody
HFE 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, IHC, ICC 宿主: 兔 Polyclonal unconjugated

anti-Hemochromatosis (HFE) (AA 149-198) antibody
HFE 适用: 人, 大鼠, 犬, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Hemochromatosis (HFE) (AA 80-306) antibody
HFE 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-Hemochromatosis (HFE) (C-Term) antibody
HFE 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Hemochromatosis (HFE) antibody
HFE 适用: 人, 小鼠 IF 宿主: 兔 Polyclonal unconjugated

anti-Hemochromatosis (HFE) (AA 1-348) antibody
HFE 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-Hemochromatosis (HFE) (AA 35-84) antibody
HFE 适用: 人, 小鼠, 兔, Pig WB 宿主: 兔 Polyclonal unconjugated

应用备注

WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

有效期

12 months
Rychtarcikova, Lettlova, Tomkova, Korenkova, Langerova, Simonova, Zjablovskaja, Alberich-Jorda, Neuzil, Truksa: "Tumor-initiating cells of breast and prostate origin show alterations in the expression of genes related to iron metabolism." in: Oncotarget, Vol. 8, Issue 4, pp. 6376-6398, (2016) (PubMed).
抗原

HFE (Hemochromatosis (HFE))

别名

HFE/Hemochromatosis (HFE 产品)

别名

HFE1 antibody, HH antibody, HLA-H antibody, MVCD7 antibody, TFQTL2 antibody, MR2 antibody, hemochromatosis antibody, HFE antibody, Hfe antibody

背景

Synonyms: dJ221C16.10.1, Hemochromatosis, Hemochromatosis protein, Hereditary hemochromatosis protein, Hereditary hemochromatosis protein HLA H, HFE 1, HFE, HFE_HUMAN, HFE1, HH, High Fe, HLA H, HLA-H, HLAH, MGC:150812, MGC10379, MGC103790, MHC class I like protein HFE, MVCD7, TFQTL2.
Background: The features of hemochromatosis include cirrhosis of the liver, diabetes, hypermelanotic pigmentation of the skin, and heart failure. Since hemochromatosis is a relatively easily treated disorder if diagnosed, this is a form of preventable cancer. The HFE protein, which is defective in hereditary hemo-chromatosis, normally is expressed in crypt enterocytes of the duodenum where it has a unique, predominantly intracellular localization. In placenta, the HFE protein co-localizes with and forms a stable association with the transferrin receptor (TfR), providing a link between the HFE protein and iron transport. Immunocytochemistry shows that the HFE protein and TfR both are expressed in the crypt enterocytes. Western blots show that, as is the case in human placenta, the HFE protein in crypt enterocytes is physically associated with the TfR and with _2-microglobulin. It is proposed that HFE has two mutually exclusive activities in cells: inhibition of uptake or inhibition of release of iron and that the balance between serum transferrin saturation and serum transferrin-receptor concentrations determines which of these functions predominates. The gene which encodes HFE maps to human chromosome 6p21.3.

基因ID

3077

途径

Transition Metal Ion Homeostasis, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process