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HES2 抗体 (AA 1-100)

HES2 适用: 小鼠 WB, ELISA, IF (cc), IF (p), IHC (fro), IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN1714558
发货至: 中国
  • 抗原 See all HES2 抗体
    HES2 (Hairy and Enhancer of Split 2 (HES2))
    抗原表位
    • 14
    • 4
    • 3
    • 1
    • 1
    • 1
    AA 1-100
    适用
    • 24
    • 18
    • 12
    小鼠
    宿主
    • 31
    • 3
    克隆类型
    • 31
    • 3
    多克隆
    标记
    • 10
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This HES2 antibody is un-conjugated
    应用范围
    • 21
    • 12
    • 12
    • 11
    • 4
    • 2
    • 2
    • 2
    Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)
    交叉反应
    小鼠
    预测反应
    Human,Rat,Dog,Cow,Horse
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic peptide derived from human HES2
    亚型
    IgG
    Top Product
    Discover our top product HES2 Primary Antibody
  • 应用备注
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    有效期
    12 months
  • 抗原
    HES2 (Hairy and Enhancer of Split 2 (HES2))
    别名
    HES2 (HES2 产品)
    别名
    HES2 antibody, bHLHb40 antibody, HES-2 antibody, hes family bHLH transcription factor 2 antibody, hairy and enhancer of split 2 (Drosophila) antibody, HES2 antibody, Hes2 antibody
    背景

    Synonyms: bHLHb40, Class B basic helix loop helix protein 40, Hairy and enhancer of split 2 Drosophila, Transcription factor HES 2, HES2_HUMAN.

    Background: The Drosophila hairy and Enhancer of split genes encode basic helix-loop-helix (bHLH) transcriptional repressors that function in the Notch signaling pathway and control segmentation and neural development during embryogenesis. The mammalian homologues of Drosophila hairy and Enhancer of split are the HES gene family members, HES1-6, which also encode bHLH transcriptional repressors that regulate myogenesis and neurogenesis. The HES family members form a complex with TLE, the mammalian homologue of Groucho, and this interaction is mediated by the carboxy terminal WRPW motif of the HES proteins. The HES/TLE complex functions by directly binding to DNA, instead of interfering with activator proteins. Most HES family members, including HES1 and HES5, preferentially bind to the N box (CACNAG) as opposed to the E box (CANNTG). HES2 binds to both N and E box sites, while HES6 does not bind DNA. Rather, HES6 inhibits HES1 activity, thereby promoting transcription. HES1 and HES2 are expressed in a variety of adult and embryonic tissues. HES3 is expressed exclusively in cerebellar Purkinje cells, and HES5 is found solely in the nervous system. HES6 is produced in brain as well as in the limb buds of developing embryos.

    基因ID
    54626
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