SOCS5 抗体 (AA 151-250)
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- 抗原 See all SOCS5 抗体
- SOCS5 (Suppressor of Cytokine Signaling 5 (SOCS5))
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抗原表位
- AA 151-250
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This SOCS5 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)
- 预测反应
- Human,Mouse,Rat,Cow,Sheep,Chicken
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human SOCS5
- 亚型
- IgG
- Top Product
- Discover our top product SOCS5 Primary Antibody
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anti-Suppressor of Cytokine Signaling 5 (SOCS5) (N-Term) antibody
SOCS5 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Suppressor of Cytokine Signaling 5 (SOCS5) (AA 1-110) antibodySOCS5 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 2D1 unconjugated
anti-Suppressor of Cytokine Signaling 5 (SOCS5) (AA 1-140) antibodySOCS5 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Suppressor of Cytokine Signaling 5 (SOCS5) (AA 1-270) antibodySOCS5 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Suppressor of Cytokine Signaling 5 (SOCS5) antibodySOCS5 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Suppressor of Cytokine Signaling 5 (SOCS5) (AA 1-536) antibodySOCS5 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Suppressor of Cytokine Signaling 5 (SOCS5) (AA 1-536) antibodySOCS5 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Suppressor of Cytokine Signaling 5 (SOCS5) (AA 1-270) antibodySOCS5 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- 有效期
- 12 months
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- 抗原
- SOCS5 (Suppressor of Cytokine Signaling 5 (SOCS5))
- 别名
- SOCS5 (SOCS5 产品)
- 别名
- SOCS5 antibody, cis6 antibody, cish5 antibody, cish6 antibody, socs-5 antibody, GB18949 antibody, socs5 antibody, zgc:153506 antibody, CIS6 antibody, CISH6 antibody, Cish5 antibody, SOCS-5 antibody, 1810018L08Rik antibody, mKIAA0671 antibody, RGD1564914 antibody, suppressor of cytokine signaling 5 antibody, suppressor of cytokine signaling 5a antibody, suppressor of cytokine signaling 5 L homeolog antibody, SOCS5 antibody, socs5 antibody, LOC552036 antibody, socs5a antibody, Tsp_07018 antibody, socs5.L antibody, Socs5 antibody
- 背景
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Synonyms: CIS-6, CIS6, CISH5, CISH6, Cytokine inducible SH2 containing protein 5, Cytokine inducible SH2 protein 6, KIAA0671, SOCS-5, Suppressor of cytokine signaling 5.
Background: The eight members of the recently identified Suppressor of Cytokines Signaling (SOCS) family are SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS6, SOCS7, and CIS. Structurally the SOCS proteins are composed of an N- terminal region of variable length and amino acid composition, a central SH2 domain, and a C-terminal motif called the SOCS box. The SOCS proteins appear to form part of a classical negative feedback loop that regulates cytokine signal transduction. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways. During Th1 differentiation a reduction in the association of Jak1 with the IL4 Receptor correlated with the appearance of SOCS5. SOCS5 protein was preferentially expressed in committed Th1 cells and interacted with the cytoplasmic region of the IL4 Receptor alpha chain irrespective of receptor tyrosine phosphorylation. This unconventional interaction of SOCS5 protein with IL4 Receptor resulted in the inhibition of IL4-mediated signal transducer and activator of transcription-6 activation. T cells from transgenic mice constitutively expressing SOCS5 exhibited a significant reduction of IL4-mediated Th2 development. Therefore, the induced SOCS5 protein in Th1 differentiation environment may play an important role by regulating Th1 and Th2 balance.
- 途径
- JAK/STAT Signaling, EGFR Signaling Pathway, Positive Regulation of Immune Effector Process
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