PTK6 抗体 (pTyr447)
(1 reference)-
- 抗原 See all PTK6 抗体
- PTK6 (PTK6 Protein tyrosine Kinase 6 (PTK6))
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抗原表位
- pTyr447
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PTK6 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))
- 交叉反应
- 人
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic phosphopeptide derived from human Brk around the phosphorylation site of Tyr447 [TS(p-Y)EN]
- 亚型
- IgG
- Top Product
- Discover our top product PTK6 Primary Antibody
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anti-PTK6 Protein tyrosine Kinase 6 (PTK6) (AA 1-451) antibody
PTK6 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-PTK6 Protein tyrosine Kinase 6 (PTK6) antibodyPTK6 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-PTK6 Protein tyrosine Kinase 6 (PTK6) (AA 222-451) antibodyPTK6 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-PTK6 Protein tyrosine Kinase 6 (PTK6) (AA 191-445) antibodyPTK6 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-PTK6 Protein tyrosine Kinase 6 (PTK6) (AA 1-113) antibodyPTK6 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-PTK6 Protein tyrosine Kinase 6 (PTK6) (AA 342-451) antibodyPTK6 适用: 人 ELISA, IHC (p) 宿主: 小鼠 Monoclonal 2F11 unconjugated
anti-PTK6 Protein tyrosine Kinase 6 (PTK6) antibodyPTK6 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2H12B8 unconjugated
anti-PTK6 Protein tyrosine Kinase 6 (PTK6) (AA 11-41), (N-Term) antibodyPTK6 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB3073-3074 unconjugated
anti-PTK6 Protein tyrosine Kinase 6 (PTK6) (AA 287-336) antibodyPTK6 适用: 人, 马 WB 宿主: 兔 Polyclonal unconjugated
anti-PTK6 Protein tyrosine Kinase 6 (PTK6) (AA 342-452) antibodyPTK6 适用: 人 ELISA 宿主: 小鼠 Monoclonal 2F11 unconjugated
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- 应用备注
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WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- 有效期
- 12 months
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: "The marine-derived sipholenol A-4-O-3',4'-dichlorobenzoate inhibits breast cancer growth and motility in vitro and in vivo through the suppression of Brk and FAK signaling." in: Marine drugs, Vol. 12, Issue 4, pp. 2282-304, (2014) (PubMed).
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: "The marine-derived sipholenol A-4-O-3',4'-dichlorobenzoate inhibits breast cancer growth and motility in vitro and in vivo through the suppression of Brk and FAK signaling." in: Marine drugs, Vol. 12, Issue 4, pp. 2282-304, (2014) (PubMed).
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- 抗原
- PTK6 (PTK6 Protein tyrosine Kinase 6 (PTK6))
- 别名
- Brk (PTK6 产品)
- 别名
- BRK antibody, Sik antibody, Tksk antibody, tks antibody, zgc:153964 antibody, protein tyrosine kinase 6 antibody, PTK6 protein tyrosine kinase 6 antibody, PTK6 protein tyrosine kinase 6b antibody, PTK6 antibody, Ptk6 antibody, ptk6b antibody
- 背景
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Synonyms: BRK, Protein-tyrosine kinase 6, Breast tumor kinase, Tyrosine-protein kinase BRK, PTK6
Background: Non-receptor tyrosine-protein kinase implicated in the regulation of a variety of signaling pathways that control the differentiation and maintenance of normal epithelia, as well as tumor growth. Function seems to be context dependent and differ depending on cell type, as well as its intracellular localization. A number of potential nuclear and cytoplasmic substrates have been identified. These include the RNA-binding proteins: KHDRBS1/SAM68, KHDRBS2/SLM1, KHDRBS3/SLM2 and SFPQ/PSF, transcription factors: STAT3 and STAT5A/B and a variety of signaling molecules: ARHGAP35/p19RhoGAP, PXN/paxillin, BTK/ATK, STAP2/BKS. Associates also with a variety of proteins that are likely upstream of PTK6 in various signaling pathways, or for which PTK6 may play an adapter-like role. These proteins include ADAM15, EGFR, ERBB2, ERBB3 and IRS4. In normal or non-tumorigenic tissues, PTK6 promotes cellular differentiation and apoptosis. In tumors PTK6 contributes to cancer progression by sensitizing cells to mitogenic signals and enhancing proliferation, anchorage-independent survival and migration/invasion. Association with EGFR, ERBB2, ERBB3 may contribute to mammary tumor development and growth through enhancement of EGF-induced signaling via BTK/AKT and PI3 kinase. Contributes to migration and proliferation by contributing to EGF-mediated phosphorylation of ARHGAP35/p19RhoGAP, which promotes association with RASA1/p12RasGAP, inactivating RhoA while activating RAS. EGF stimulation resulted in phosphorylation of PNX/Paxillin by PTK6 and activation of RAC1 via CRK/CrKII, thereby promoting migration and invasion. PTK6 activates STAT3 and STAT5B to promote proliferation. Nuclear PTK6 may be important for regulating growth in normal epithelia, while cytoplasmic PTK6 might activate oncogenic signaling pathways. Isoform 2 inhibits PTK6 phosphorylation and PTK6 association with other tyrosine-phosphorylated proteins.
- 基因ID
- 5753
- UniProt
- Q13882
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