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DPPA3 抗体 (AA 101-159)

DPPA3 适用: 小鼠, Pig WB, ELISA, ICC, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN1713577
发货至: 中国
  • 抗原 See all DPPA3 抗体
    DPPA3 (Developmental Pluripotency Associated 3 (DPPA3))
    抗原表位
    • 7
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 101-159
    适用
    • 20
    • 11
    • 1
    小鼠, Pig
    宿主
    • 20
    • 1
    • 1
    克隆类型
    • 22
    多克隆
    标记
    • 11
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This DPPA3 antibody is un-conjugated
    应用范围
    Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    交叉反应
    小鼠, Pig
    预测反应
    Human
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic peptide derived from human Stella/DPPA3
    亚型
    IgG
  • 应用备注
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    有效期
    12 months
  • Wasielak, Więsak, Bogacka, Jalali, Bogacki: "Zygote arrest 1, nucleoplasmin 2, and developmentally associated protein 3 mRNA profiles throughout porcine embryo development in vitro." in: Theriogenology, Vol. 86, Issue 9, pp. 2254-2262, (2016) (PubMed).

  • 抗原
    DPPA3 (Developmental Pluripotency Associated 3 (DPPA3))
    别名
    Stella/DPPA3 (DPPA3 产品)
    别名
    STELLA antibody, 2410075G02Rik antibody, PCG7 antibody, PGC7 antibody, Stella antibody, developmental pluripotency associated 3 antibody, developmental pluripotency-associated 3 antibody, DPPA3 antibody, Dppa3 antibody
    背景

    Synonyms: STELLA, Developmental pluripotency-associated protein 3, Stella-related protein, DPPA3, STELLAR

    Background: Primordial germ cell (PGCs)-specific protein involved in epigenetic chromatin reprogramming in the zygote following fertilization. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in protection of DNA methylation in the maternal pronucleus by preventing conversion of 5mC to 5hmC: specifically recognizes and binds histone H3 dimethylated at 'Lys-9' (H3K9me2) on maternal genome, and protects maternal genome from TET3-mediated conversion to 5hmC and subsequent DNA demethylation. Does not bind paternal chromatin, which is mainly packed into protamine and does not contain much H3K9me2 mark. Also protects imprinted loci that are marked with H3K9me2 in mature sperm from DNA demethylation in early embryogenesis. May be important for the totipotent/pluripotent states continuing through preimplantation development. Also involved in chromatin condensation in oocytogenesis (By similarity).

    基因ID
    359787
    UniProt
    Q6W0C5
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