GUCY1A2 抗体 (AA 401-500) (Biotin)
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- 抗原 See all GUCY1A2 products
- GUCY1A2 (Guanylyl Cyclase alpha 2)
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抗原表位
- AA 401-500
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This GUCY1A2 antibody is conjugated to Biotin
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro))
- 预测反应
- Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Rabbit
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human Guanylyl Cyclase alpha 2
- 亚型
- IgG
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anti-Guanylyl Cyclase alpha 2 (AA 699-732), (C-Term) antibody
适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB7755 unconjugated
anti-Guanylyl Cyclase alpha 2 (AA 105-136), (N-Term) antibody适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C for 12 months.
- 有效期
- 12 months
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- 抗原
- GUCY1A2 (Guanylyl Cyclase alpha 2)
- Abstract
- GUCY1A2 产品
- 别名
- GC-SA2 antibody, GUC1A2 antibody, guanylate cyclase 1 soluble subunit alpha 2 antibody, GUCY1A2 antibody
- 背景
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Synonyms: GC SA2, GCS-alpha 2, GUC1A2, GUCSA2, GCYA2_HUMAN.
Background: Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase. The soluble form, known as GCS or sGC, act as receptors for nitric oxide (NO). The membrane-bound receptor form, known as GC, are peptide hormone receptors. GCS is a cGMP-synthesizing enzyme, which is the major receptor for the neurotransmitter nitric oxide. It plays a crucial role in smooth muscle contractility, platelet reactivity and neurotransmission. GCS is a heme-containing heterodimer, consisting of one alpha subunit and one beta subunit. The heme moeity mediates NO activation, and this heme group also binds carbon monoxide (CO), which weakly stimulates the enzyme. Both NO and CO stimulation are enhanced by the allosteric activator 3-(5'-hydroxymethyl-2'furyl)-benzyl-indazole, YC-1. YC-1 can also stimulate GCS in a NO-independent manner. Both alpha and beta subunits are required for cGMP generation, and at least two isoforms exist for each subunit. Heterodimers consisting of alpha-1/beta-1 and alpha-2/beta-1 have been identified, and both display similar enzymatic activity. The distribution of the beta-2 subunit seems to be much more restricted than the beta-1 subunit, with predominant expression in kidney and liver.
- 基因ID
- 2977
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