GAB4 抗体 (AA 101-200) (Biotin)
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- 抗原 See all GAB4 products
- GAB4 (GRB2-Associated Binding Protein Family, Member 4 (GAB4))
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抗原表位
- AA 101-200
- 适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This GAB4 antibody is conjugated to Biotin
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- 预测反应
- Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human GAB4
- 亚型
- IgG
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anti-GRB2-Associated Binding Protein Family, Member 4 (GAB4) (AA 64-92), (N-Term) antibody
GAB4 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB29443 unconjugated
anti-GRB2-Associated Binding Protein Family, Member 4 (GAB4) (AA 71-100), (N-Term) antibodyGAB4 适用: 人 WB, FACS, EIA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C for 12 months.
- 有效期
- 12 months
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- 抗原
- GAB4 (GRB2-Associated Binding Protein Family, Member 4 (GAB4))
- 别名
- GAB4 (GAB4 产品)
- 别名
- GRB2 associated binding protein family member 4 antibody, GAB4 antibody
- 背景
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Synonyms: GAB2-like, GAB4, GAB4_HUMAN, GRB2 associated binder 2 like protein, GRB2 associated binding protein family member 4, GRB2-associated binder 2-like, GRB2-associated binder 4, GRB2-associated-binding protein 2-like, GRB2-associated-binding protein 4, Growth factor receptor bound protein 2-associated protein 4.
Background: The Gab family of adaptor proteins function as molecular scaffolds that mediate protein recruit-ment to RTKs. Cytokine/growth factor triggering of protein tyrosine kinase receptors (RTKs) initiates signaling cascades that progress to the nucleus where signals for activation, proliferation and differentiation occur. This scaffolding mechanism represents a critical link in cytokine/growth factor signaling routes. Gab 1-4 contain Pleckstrin homology and potential binding sites for SH2 and SH3 domain-containing proteins. The recruitment of signaling partners to Gab family members is phosphorylation-dependent. Insulin receptor and EGF receptor signaling are among the cascades that rely on Gab family members to elicit a nuclear response to an extracellular stimulus. Gab 4 (GRB2-associated-binding protein 4), also designated GRB2-associated-binding protein 2-like (Gab 2-like), is a 574 amino acid protein that shares 62 % sequence similarity with Gab 2 and contains one Pleckstrin homology domain.
- 基因ID
- 128954
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