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FRAT2 抗体 (AA 131-230) (Biotin)

FRAT2 适用: 小鼠 WB, ELISA, IHC (p), IHC (fro) 宿主: 兔 Polyclonal Biotin
产品编号 ABIN1701037
发货至: 中国
  • 抗原 See all FRAT2 抗体
    FRAT2 (Frequently Rearranged in Advanced T-Cell Lymphomas 2 (FRAT2))
    抗原表位
    • 14
    • 9
    • 8
    • 7
    • 1
    AA 131-230
    适用
    • 17
    • 14
    小鼠
    宿主
    • 29
    • 1
    • 1
    克隆类型
    • 31
    多克隆
    标记
    • 8
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This FRAT2 antibody is conjugated to Biotin
    应用范围
    • 30
    • 15
    • 14
    • 13
    • 13
    • 13
    • 7
    • 5
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    交叉反应
    小鼠
    预测反应
    Human,Rat,Dog,Cow,Sheep
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic peptide derived from human FRAT2
    亚型
    IgG
    Top Product
    Discover our top product FRAT2 Primary Antibody
  • 应用备注
    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C for 12 months.
    有效期
    12 months
  • 抗原
    FRAT2 (Frequently Rearranged in Advanced T-Cell Lymphomas 2 (FRAT2))
    别名
    FRAT2 (FRAT2 产品)
    别名
    FRAT2 antibody, FRAT2, WNT signaling pathway regulator antibody, frequently rearranged in advanced T cell lymphomas 2 antibody, frequently rearranged in advanced T-cell lymphomas 2 antibody, FRAT2 antibody, Frat2 antibody
    背景

    Synonyms: Frequently rearranged in advanced T-cell lymphomas 2 antibodyGSK-3 binding protein FRAT2, FRAT2_HUMAN.

    Background: FRAT1 and FRAT2 were originally characterized as proteins frequently rearranged in advanced T cell lymphoma, and they have since been identified as proto-oncogenes involved in tumorigenesis. These proteins share significant homology with the Xenopus glycogen synthase kinase-3 (xGSK-3) binding protein, which is designated GBP and is essential for the formation of the dorsal-ventral axis during embryonic development. Establishment of these embryonic axes is mediated by the Wnt intracellular signaling pathway. Wnt signaling is regulated in part by the activity of GSK-3, which phosphorylates and thereby facilitates the degradation of ?catenin. GBP binds to GSK-3 and inhibits this phosphorylation, resulting in the accumulation of ?catenin and the subsequent transcription of Wnt target genes. Like GBP, FRAT2 has been shown to bind xGSK-3, suggesting that FRAT1 and FRAT2 may be GSK-3 regulatory proteins.

    基因ID
    23401
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