HIC1 抗体 (AA 501-650) (Biotin)
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- 抗原 See all HIC1 抗体
- HIC1 (Hypermethylated in Cancer 1 (HIC1))
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抗原表位
- AA 501-650
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适用
- 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This HIC1 antibody is conjugated to Biotin
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 交叉反应
- 小鼠
- 预测反应
- Human,Rat,Dog,Cow,Pig,Horse,Chicken
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human HIC1
- 亚型
- IgG
- Top Product
- Discover our top product HIC1 Primary Antibody
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anti-Hypermethylated in Cancer 1 (HIC1) (AA 396-453) antibody
HIC1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 4E11 unconjugated
anti-Hypermethylated in Cancer 1 (HIC1) (AA 396-453) antibodyHIC1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1E11 unconjugated
anti-Hypermethylated in Cancer 1 (HIC1) (AA 297-418) antibodyHIC1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Hypermethylated in Cancer 1 (HIC1) (AA 193-204) antibodyVerified HIC1 适用: 小鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Hypermethylated in Cancer 1 (HIC1) antibodyHIC1 适用: 人, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Hypermethylated in Cancer 1 (HIC1) (AA 627-705) antibodyHIC1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1F2 unconjugated
anti-Hypermethylated in Cancer 1 (HIC1) (AA 209-258) antibodyHIC1 适用: 人, 小鼠, 大鼠, 豚鼠, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Hypermethylated in Cancer 1 (HIC1) (AA 215-264) antibodyHIC1 适用: 人, 小鼠, 大鼠, 犬, Cow, 猴, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Hypermethylated in Cancer 1 (HIC1) (AA 899-948) antibodyHIC1 适用: 人, 豚鼠, 犬, Cow, Pig, 猴, 马, Bat WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C for 12 months.
- 有效期
- 12 months
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- 抗原
- HIC1 (Hypermethylated in Cancer 1 (HIC1))
- 别名
- HIC1 (HIC1 产品)
- 别名
- zfHIC1 antibody, HIC1 antibody, ZBTB29 antibody, ZNF901 antibody, hic-1 antibody, AA408311 antibody, HIC-1 antibody, hypermethylated in cancer 1 antibody, HIC ZBTB transcriptional repressor 1 antibody, hic1 antibody, HIC1 antibody, Hic1 antibody
- 背景
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Synonyms: Hic 1, Hic-1, Hic1, HIC1_HUMAN, Hypermethylated in cancer 1, Hypermethylated in cancer 1 protein, ZBTB29, Zinc finger and BTB domain-containing protein 29, ZNF901.
Background: Hypermethylated in cancer (HIC-1) was originally identified as a target of p53-induced gene expression. HIC-1 is deleted in the genetic disorder Miller-Dieker syndrome (MDS), and the expression of HIC-1 is also frequently suppressed in leukemia and various cancers due to the hypermethylation of specific DNA regions and the resulting transcriptional silencing. These and other studies indicate that HIC-1 acts as a putative tumor suppressor protein that mediates transcriptional repression. HIC-1 is ubiquitously expressed in adult tissues and its structure is defined by five zinc fingers and an N-terminal broad complex POZ (or BTB) domain. In several BTB/POZ containing proteins, including BCL-6 and the promyelocytic leukemia zinc-finger (PLZF) oncoprotein, this domain interacts with the SMRT/N-CoR-mSin3A HDAC complex and is directly involved in repressing and silencing gene transcription. When this domain is deleted, as with the oncogenic PLZF-RAR chimera of promyelocytic leukemias, this transcriptional repression is attenuated. Conversely, HIC-1 does not interact with components of the HDAC complex, suggesting that HIC-1-induced transcriptional repression is unassociated with the POZ/BTB domain.
- 基因ID
- 3090
- 途径
- Positive Regulation of Response to DNA Damage Stimulus
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