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GRB7 抗体 (AA 231-330) (Biotin)

GRB7 适用: 人 ELISA, IHC (p), IHC (fro) 宿主: 兔 Polyclonal Biotin
产品编号 ABIN1700331
发货至: 中国
  • 抗原 See all GRB7 抗体
    GRB7 (Growth Factor Receptor-Bound Protein 7 (GRB7))
    抗原表位
    • 14
    • 7
    • 7
    • 6
    • 6
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 231-330
    适用
    • 58
    • 15
    • 13
    • 1
    • 1
    • 1
    • 1
    • 1
    宿主
    • 55
    • 3
    • 1
    • 1
    克隆类型
    • 59
    • 1
    多克隆
    标记
    • 30
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This GRB7 antibody is conjugated to Biotin
    应用范围
    • 36
    • 26
    • 13
    • 13
    • 10
    • 5
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    预测反应
    Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic peptide derived from human GRB7
    亚型
    IgG
    Top Product
    Discover our top product GRB7 Primary Antibody
  • 应用备注
    IHC-P 1:200-400
    IHC-F 1:100-500
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C for 12 months.
    有效期
    12 months
  • 抗原
    GRB7 (Growth Factor Receptor-Bound Protein 7 (GRB7))
    别名
    GRB7 (GRB7 产品)
    别名
    GRB7 antibody, mKIAA4028 antibody, growth factor receptor bound protein 7 antibody, GRB7 antibody, Grb7 antibody
    背景

    Synonyms: B47, Epidermal growth factor receptor GRB 7, Epidermal growth factor receptor GRB-7, GRB7 adapter protein, GRB7, GRB7_HUMAN, Growth factor receptor bound protein 7, Growth factor receptor-bound protein 7, OTTHUMP00000164349, OTTHUMP00000164350, OTTHUMP00000164351, OTTHUMP00000164352.

    Background: Many growth factors function by binding receptors with intrinsic tyrosine kinase activity (1,2). Signaling by such receptors involves a series of intermediates characterized by SH2 domains that bind tyrosine phosphorylated receptors by a direct interaction between the SH2 domain and the phosphotyrosine-containing receptor sequences (3,4). GRB7, a SH2 domain protein, has a single SH2 domain at its C-terminal, a central region with similarity to Ras GAP and a proline-rich N-terminus (5,6). GRB7 maps to the region on mouse chromosome 11 containing the Neu gene (6). This region of mouse chromosome 11 is syntenic to an area of human chromosome 17q that is frequently amplified in breast cancer (6,7). Moreover, GRB7 is amplified and over-expressed in breast cancer and is found in a complex with Neu gp185 (6).

    途径
    EGFR Signaling Pathway, Ribonucleoprotein Complex Subunit Organization
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