GRB14 抗体 (AA 221-320) (Biotin)
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- 抗原 See all GRB14 抗体
- GRB14 (Growth Factor Receptor-Bound Protein 14 (GRB14))
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抗原表位
- AA 221-320
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This GRB14 antibody is conjugated to Biotin
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应用范围
- ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- 特异性
- This antibody may also detect the similar protein GRB10 due to an 83 % sequence similarity in the immunogen sequence.
- 交叉反应
- 人
- 预测反应
- Mouse,Rat,Dog,Cow,Sheep,Horse,Chicken,Rabbit
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human GRB 14
- 亚型
- IgG
- Top Product
- Discover our top product GRB14 Primary Antibody
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- 应用备注
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IHC-P 1:200-400
IHC-F 1:100-500 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C for 12 months.
- 有效期
- 12 months
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- 抗原
- GRB14 (Growth Factor Receptor-Bound Protein 14 (GRB14))
- 别名
- GRB 14 (GRB14 产品)
- 别名
- GRB14 antibody, AI505286 antibody, growth factor receptor bound protein 14 antibody, GRB14 antibody, grb14 antibody, Grb14 antibody
- 背景
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Synonyms: Growth factor receptor-bound protein 14, GRB14 adapter protein, GRB14
Background: Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.
- 基因ID
- 2888
- UniProt
- Q14449
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