DCLRE1C 抗体 (AA 301-400) (AbBy Fluor® 350)
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- 抗原 See all DCLRE1C 抗体
- DCLRE1C (DNA Cross-Link Repair 1C (DCLRE1C))
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抗原表位
- AA 301-400
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适用
- 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This DCLRE1C antibody is conjugated to AbBy Fluor® 350
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应用范围
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- 交叉反应
- 大鼠
- 预测反应
- Human,Mouse,Cow,Horse
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human DCLREC1C/Artemis
- 亚型
- IgG
- Top Product
- Discover our top product DCLRE1C Primary Antibody
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anti-DNA Cross-Link Repair 1C (DCLRE1C) (C-Term) antibody
DCLRE1C 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-DNA Cross-Link Repair 1C (DCLRE1C) (AA 21-50) antibodyDCLRE1C 适用: 人, 小鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-DNA Cross-Link Repair 1C (DCLRE1C) (AA 482-495) antibodyDCLRE1C 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-DNA Cross-Link Repair 1C (DCLRE1C) (AA 301-400) antibodyDCLRE1C 适用: 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-DNA Cross-Link Repair 1C (DCLRE1C) (AA 1-434) antibodyDCLRE1C 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-DNA Cross-Link Repair 1C (DCLRE1C) (AA 396-445) antibodyDCLRE1C 适用: 人, 大鼠, 豚鼠, 马, 犬, 猴, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-DNA Cross-Link Repair 1C (DCLRE1C) (N-Term) antibodyDCLRE1C 适用: 人, 小鼠, 大鼠, 豚鼠, 马, Cow, 兔, 斑马鱼, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-DNA Cross-Link Repair 1C (DCLRE1C) (AA 21-50), (N-Term) antibodyDCLRE1C 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB24410 unconjugated
anti-DNA Cross-Link Repair 1C (DCLRE1C) (AA 482-531), (pSer516) antibodyDCLRE1C 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-DNA Cross-Link Repair 1C (DCLRE1C) (AA 482-531) antibodyDCLRE1C 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- 有效期
- 12 months
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- 抗原
- DCLRE1C (DNA Cross-Link Repair 1C (DCLRE1C))
- 别名
- DCLREC1C/Artemis (DCLRE1C 产品)
- 别名
- artemis antibody, A-SCID antibody, DCLREC1C antibody, RS-SCID antibody, SCIDA antibody, SNM1C antibody, hSNM1C antibody, Snm1l antibody, nuclease antibody, 9930121L06Rik antibody, AI661365 antibody, Art antibody, DNA cross-link repair 1C antibody, DCLRE1C antibody, Dclre1c antibody
- 背景
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Synonyms: SCIDA, SNM1C, A-SCID, RS-SCID, DCLREC1C, Protein artemis, DNA cross-link repair 1C protein, Protein A-SCID, SNM1 homolog C, hSNM1C, SNM1-like protein, DCLRE1C, ARTEMIS, ASCID
Background: Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments. V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs). These DSBs present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends. These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and signal joints respectively. This protein exhibits single-strand specific 5'-3' exonuclease activity in isolation and acquires endonucleolytic activity on 5' and 3' hairpins and overhangs when in a complex with PRKDC. The latter activity is required specifically for the resolution of closed hairpins prior to the formation of the coding joint. May also be required for the repair of complex DSBs induced by ionizing radiation, which require substantial end-processing prior to religation by NHEJ.
- 基因ID
- 64421
- UniProt
- Q96SD1
- 途径
- DNA Damage Repair
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