This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs).,GRK5,GPRK5,Signal Transduction,G protein signaling,G-Protein-Coupled Receptors(GPCR),Kinase,Immunology & Inflammation,Cardiovascular,Blood,Blood Pressure regulation,Cardiovascular diseases,Hypertension,GRK5