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APAF1 抗体 (AA 1-250)
APAF1
适用: 人
WB, IF
宿主: 兔
Polyclonal
unconjugated
APAF1抗体详情
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抗原
See all APAF1 抗体
APAF1
(Apoptotic Peptidase Activating Factor 1 (APAF1))
抗原表位
All epitopes for APAF1 抗体
AA 1-250
适用
All reactivities for APAF1 抗体
人
宿主
All hosts for APAF1 抗体
兔
克隆类型
All clonalities for APAF1 抗体
多克隆
标记
All conjugates for APAF1 抗体
This APAF1 antibody is un-conjugated
应用范围
All applications for APAF1 抗体
Western Blotting (WB), Immunofluorescence (IF)
序列
MDAKARNCLL QHREALEKDI KTSYIMDHMI SDGFLTISEE EKVRNEPTQQ QRAAMLIKMI LKKDNDSYVS FYNALLHEGY KDLAALLHDG IPVVSSSSGK DSVSGITSYV RTVLCEGGVP QRPVVFVTRK KLVNAIQQKL SKLKGEPGWV TIHGMAGCGK SVLAAEAVRD HSLLEGCFPG GVHWVSVGKQ DKSGLLMKLQ NLCTRLDQDE SFSQRLPLNI EEAKDRLRIL MLRKHPRSLL ILDDVWDSWV
交叉反应
人, 小鼠, 大鼠
产品特性
Polyclonal Antibodies
纯化方法
Affinity purification
免疫原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human APAF1 (NP_863651.1).
亚型
IgG
Alternatives
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使用细节
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应用备注
WB,1:500 - 1:2000,IF,1:50 - 1:200
限制
仅限研究用
贮存及处理
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缓冲液
PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
储存液
Sodium azide
注意事项
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件
-20 °C
储存方法
Store at -20°C. Avoid freeze / thaw cycles.
APAF1目标详情
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抗原
APAF1
(Apoptotic Peptidase Activating Factor 1 (APAF1))
别名
APAF1 (APAF1 产品 )
别名
APAF1 antibody, ARK antibody, Apaf-1 antibody, Apaf1 antibody, CG6829 antibody, D-Apaf-1 antibody, DARK antibody, Dapaf-1 antibody, Dapaf-1/HAC-1 antibody, Dark antibody, Dark/Apaf-I antibody, Dark/Dapaf-1/HAC1 antibody, Dark/Hac-1/dApaf-1 antibody, Dark/Hac-1/dApaf1 antibody, Dmel\\CG6829 antibody, Hac-1 antibody, Hac-1/Dark antibody, Hac1 antibody, T1 antibody, anon-53Fa antibody, apaf-1 antibody, apaf1 antibody, arc antibody, ark antibody, dAPAF-1 antibody, dApaf-1 antibody, dApaf-1/DARK/HAC-1 antibody, dApaf1 antibody, dArk antibody, dapaf antibody, dapaf-1 antibody, dapaf-1L antibody, dapaf-1S antibody, dark antibody, dark/dapaf-1/hac-1 antibody, dark/hac-1/dapaf-1 antibody, hac-1 antibody, hac1 antibody, l(2)SH0173 antibody, APAF-1 antibody, CED4 antibody, 6230400I06Rik antibody, Apaf1l antibody, fog antibody, mKIAA0413 antibody, zgc:136543 antibody, Death-associated APAF1-related killer antibody, apoptotic peptidase activating factor 1 L homeolog antibody, apoptotic peptidase activating factor 1 antibody, Dark antibody, apaf1.L antibody, apaf1 antibody, APAF1 antibody, Apaf1 antibody
背景
This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms.,APAF1,APAF-1,CED4,Cancer,Invasion and Metastasis,Cell Biology & Developmental Biology,Apoptosis,Mitochondrial Control of Apoptosis,Inhibition of Apoptosis,Death Receptor Signaling Pathway,Endocrine & Metabolism,Mitochondrial metabolism,Mitochondrial markers,Neuroscience,Neurodegenerative Diseases,APAF1
分子量
37 kDa/133 kDa/135 kDa/137 kDa/140 kDa/141 kDa
基因ID
317
UniProt
O14727
途径
p53 Pathway , Apoptosis , Caspase Cascade in Apoptosis , Tube Formation , Positive Regulation of Endopeptidase Activity
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