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Huntingtin 抗体 (N-Term)

Name: Huntingtin 抗体 (N-Term)
Brand: antibodies-online
SKU: ABIN1607890
Availability: OutOfStock

HTT 适用: 人, 大鼠, 小鼠 IHC, ELISA, WB, FM 宿主: 兔 Polyclonal unconjugated

Western Blot of Rabbit Anti-Huntington antibody. (Huntingtin 抗体 (N-Term))

1 image

产品编号 ABIN1607890

发货至: 中国

Datasheet as PDF

抗原 See all Huntingtin (HTT) 抗体

Huntingtin (HTT)
抗原表位
15

5

4

4

4

4

4

3

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1
N-Term
适用
63

44

37

6

3

2

2

1

1

1

1

1

1

1

1

1

1
人, 大鼠, 小鼠
宿主
59

21

2
兔
Compatible Secondaries
克隆类型
52

29
多克隆
标记
54

3

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1
This Huntingtin antibody is un-conjugated
应用范围
40

32

23

14

14

13

13

9

7

4

4

1

1

1
Immunohistochemistry (IHC), ELISA, Western Blotting (WB), Fluorescence Microscopy (FM)

交叉反应（详细）

Cross reactivity with HTT from other sources has not been determined.

纯度

Anti-Huntington was affinity purified from monospecific antiserum by immunoaffinity chromatography. This antibody is specific towards HTT. A BLAST analysis was used to suggest cross-reactivity with Human, Mouse, and Rat based on 100 % sequence homology.

内毒素水平

Low Endotoxin : No

免疫原

Huntington affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to the near N-terminus of human Huntington.
Immunogen Type: Peptide

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anti-Huntingtin (HTT) (AA 85-200) antibody
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anti-Huntingtin (HTT) (AA 81-190) antibody
HTT 适用: 人 ELISA, WB, IF 宿主: 小鼠 Monoclonal 2E10 unconjugated

anti-Huntingtin (HTT) (AA 81-190) antibody
HTT 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 1H6 unconjugated

anti-Huntingtin (HTT) (AA 782-920) antibody
HTT 适用: 小鼠 IHC, WB, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Huntingtin (HTT) antibody
HTT 适用: 人 IHC, ELISA 宿主: 兔 Monoclonal 6F2 unconjugated Recombinant Antibody

anti-Huntingtin (HTT) (AA 81-190) antibody
HTT 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 3F9 unconjugated

anti-Huntingtin (HTT) (AA 81-191) antibody
HTT 适用: 人 IHC, ELISA, WB, IHC (p) 宿主: 小鼠 Monoclonal 3F1 unconjugated

anti-Huntingtin (HTT) (AA 2703-2911) antibody
HTT 适用: 人, 兔 IHC, WB, IP, IHC (p), IHC (fro) 宿主: 小鼠 Monoclonal unconjugated

anti-Huntingtin (HTT) (AA 416-424), (pSer421) antibody
HTT 适用: 人 IHC, ELISA, WB 宿主: 兔 Polyclonal unconjugated

应用备注

Anti-Huntington antibody is useful for ELISA and Western Blot. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately ~350 kDa corresponding to the appropriate cell lysate or extract.
ELISA Dilution: 1:20.000 - 1:60.000
Immunohistochemistry Dilution: 1:100-1:500
IF Microscopy Dilution: 1:100-1:500
Western Blot Dilution: 0.1 µg/mL

限制

仅限研究用
状态

Liquid

浓度

1 mg/mL

缓冲液

0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Stabilizer: 50 % (v/v) Glycerol

储存条件

4 °C/-20 °C

储存方法

Store vial at -20 °C prior to opening. Aliquot contents and freeze at -20 °C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4 °C as an undiluted liquid. Dilute only prior to immediate use.

有效期

Expiration date is six (6) months from date of opening.
抗原

Huntingtin (HTT)

别名

Huntington (HTT 产品)

别名

HTT antibody, hd antibody, ZHD antibody, CG9995 antibody, Dmel\\CG9995 antibody, HD antibody, Hsap\\HD antibody, Htt antibody, dHtt antibody, dhtt antibody, SLC6A4 antibody, huntington antibody, it15 antibody, htt antibody, IT15 antibody, AI256365 antibody, C430023I11Rik antibody, Hd antibody, Hdh antibody, huntingtin antibody, HTT antibody, htt antibody, LOC373520 antibody, Htt antibody

背景

Huntington (also known as Huntington's disease protein, Htt and HD protein) is the protein product of a disease gene linked to Huntington's disease, a neuro-degenerative disorder characterized by loss of striatal neurons. This may be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product (see partial protein sequence below). The huntingtin gene locus is large, spanning 180 kb and consisting of 67 exons. It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues. The genetic defect leading to Huntington's disease may not necessarily eliminate transcription, but may confer a new property on the mRNA or alter the function of the protein. One candidate is the huntingtin-associated protein-1, highly expressed in brain, which has increased affinity for huntingtin protein with expanded polyglutamine repeats. Normal huntingtin protein shows a cytoplasmic localization. This protein is widely expressed with the highest level of expression in the brain (nerve fibers, varicosities, and nerve endings). In the brain, the regions where it can be mainly found are the cerebellar cortex, the neocortex, the striatum, and the hippocampal formation. Anti-Huntingtin antibodies are ideal for researchers interested in Apoptosis, Autophagy, Cytoskeleton, Neurodegeneration, Neuroscience, and Neuronal Cell Markers research. Synonyms: HD protein, HTT, huntingtin, huntingtin (Huntington disease), IT15HD, Huntington disease protein

基因ID

3064

NCBI登录号

NP_002102

UniProt

P42858

途径

PI3K-Akt Signaling, Hormone Transport, Transition Metal Ion Homeostasis, Tube Formation, Protein targeting to Nucleus, Dicarboxylic Acid Transport