(4 references)-
- 抗原 See all LYVE1 抗体
- LYVE1 (Lymphatic Vessel Endothelial Hyaluronan Receptor 1 (LYVE1))
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This LYVE1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))
- 原理
- Lyve-1 antibody
- 特异性
- Recombinant human LYVE-1
- 产品特性
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Chromosomal location: 11p15
Produced from sera of rabbits immunized with highly pure recombinant human soluble LYVE-1 produced in insect cells. The recombinant soluble LYVE-1consists of amino acid 24 (Ser) to 232 (Gly) and is fused to a C-terminal His-tag (6xHis). LYVE-1 has been identified as a major receptor for HA (extracellular matrix glycosaminoglycan hyaluronan) on the lymph vessel wall. The deduced amino acid sequence of LYVE-1 predicts a 322-residue type I integral membrane polypeptide 41% similar to the CD44 HA receptor with a 212-residue extracellular domain containing a single Link module the prototypic HA binding domain of the Link protein superfamily. Like CD44, the LYVE-1 molecule binds both soluble and immobilized HA. However, unlike CD44, the LYVE-1 molecule co-localizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE-1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves. - 纯化方法
- Protein-A purified
- 免疫原
- Recombinant human LYVE-1 (ABIN1589751)
- 亚型
- IgG
- Top Product
- Discover our top product LYVE1 Primary Antibody
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anti-Lymphatic Vessel Endothelial Hyaluronan Receptor 1 (LYVE1) (AA 231-318) antibody
LYVE1 适用: 人, 小鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Lymphatic Vessel Endothelial Hyaluronan Receptor 1 (LYVE1) (AA 46-77), (N-Term) antibodyLYVE1 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB2930 unconjugated
anti-Lymphatic Vessel Endothelial Hyaluronan Receptor 1 (LYVE1) (AA 20-238) antibodyLYVE1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Lymphatic Vessel Endothelial Hyaluronan Receptor 1 (LYVE1) (AA 24-228) antibodyLYVE1 适用: 小鼠, 大鼠 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Lymphatic Vessel Endothelial Hyaluronan Receptor 1 (LYVE1) (AA 20-238) antibodyLYVE1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Lymphatic Vessel Endothelial Hyaluronan Receptor 1 (LYVE1) antibodyLYVE1 适用: 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Lymphatic Vessel Endothelial Hyaluronan Receptor 1 (LYVE1) antibodyLYVE1 适用: 小鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Lymphatic Vessel Endothelial Hyaluronan Receptor 1 (LYVE1) (N-Term) antibodyLYVE1 适用: 人, 豚鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Lymphatic Vessel Endothelial Hyaluronan Receptor 1 (LYVE1) (AA 24-228) antibodyLYVE1 适用: 小鼠 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Western Blot: Use 2-5 μg/mL
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL.
- 缓冲液
- PBS
- 注意事项
- Centrifuge vial prior to opening.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots.
- 有效期
- 24 months
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: "Development of full-thickness human skin equivalents with blood and lymph-like capillary networks by cell coating technology." in: Journal of biomedical materials research. Part A, (2015) (PubMed).
: "Lymphangiogenesis and angiogenesis during human fetal pancreas development." in: Vascular cell, Vol. 6, pp. 22, (2015) (PubMed).
: "Molecular and cellular effects of in vitro shockwave treatment on lymphatic endothelial cells." in: PLoS ONE, Vol. 9, Issue 12, pp. e114806, (2014) (PubMed).
: "Pivotal roles of lymphatic endothelial cell layers in the permeability to hydrophilic substances through collecting lymph vessel walls: effects of inflammatory cytokines." in: Lymphatic research and biology, Vol. 12, Issue 3, pp. 124-35, (2014) (PubMed).
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: "Development of full-thickness human skin equivalents with blood and lymph-like capillary networks by cell coating technology." in: Journal of biomedical materials research. Part A, (2015) (PubMed).
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- 抗原
- LYVE1 (Lymphatic Vessel Endothelial Hyaluronan Receptor 1 (LYVE1))
- 别名
- Lyve-1 (LYVE1 产品)
- 别名
- LYVE1 antibody, XLKD1 antibody, CRSBP-1 antibody, HAR antibody, LYVE-1 antibody, 1200012G08Rik antibody, Crsbp-1 antibody, Lyve-1 antibody, Xlkd1 antibody, lymphatic vessel endothelial hyaluronic receptor 1a antibody, lymphatic vessel endothelial hyaluronan receptor 1 antibody, lyve1a antibody, LYVE1 antibody, Lyve1 antibody
- 背景
- LYVE1, HAR, XLKD1, LYVE-1, CRSBP-1,LYVE-1 has been identified as a major receptor for HA (extracellular matrix glycosaminoglycan hyaluronan) on the lymph vessel wall. The deduced amino acid sequence of LYVE-1 predicts a 322-residue type I integral membrane polypeptide 41 % similar to the CD44 HA receptor with a 212-residue extracellular domain containing a single Link module the prototypic HA binding domain of the Link protein superfamily. Like CD44, the LYVE-1 Molecule binds both soluble and immobilized HA. However, unlike CD44, the LYVE-1 Molecule colocalizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE-1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves.
- 基因ID
- 10894
- NCBI登录号
- NM_006691, NP_006682
- UniProt
- Q9Y5Y7
- 途径
- Glycosaminoglycan Metabolic Process
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