ESM1 抗体
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- 抗原 See all ESM1 抗体
- ESM1 (Endothelial Cell-Specific Molecule 1 (ESM1))
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适用
- 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This ESM1 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 原理
- Endocan/ESM-1 antibody
- 特异性
- Recombinant mouse ESM-1
- 产品特性
- Chromosomal location: 13 D2.2, 13
- 纯化方法
- Protein A purified
- 免疫原
- Recombinant mouse ESM-1 (ABIN1589771)
- 亚型
- IgG
- Top Product
- Discover our top product ESM1 Primary Antibody
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anti-Endothelial Cell-Specific Molecule 1 (ESM1) (AA 85-184) antibody
ESM1 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 6D4 unconjugated
anti-Endothelial Cell-Specific Molecule 1 (ESM1) (AA 51-150) antibodyESM1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Endothelial Cell-Specific Molecule 1 (ESM1) (AA 1-184) antibodyESM1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Endothelial Cell-Specific Molecule 1 (ESM1) (AA 20-184) antibodyESM1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Endothelial Cell-Specific Molecule 1 (ESM1) (AA 22-184) antibodyESM1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Endothelial Cell-Specific Molecule 1 (ESM1) (AA 20-184) antibodyESM1 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Endothelial Cell-Specific Molecule 1 (ESM1) (AA 22-184) antibodyESM1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Endothelial Cell-Specific Molecule 1 (ESM1) (AA 20-184) antibodyESM1 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C7 unconjugated
anti-Endothelial Cell-Specific Molecule 1 (ESM1) (AA 85-184) antibodyESM1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Endothelial Cell-Specific Molecule 1 (ESM1) (AA 1-184) antibodyESM1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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- 应用备注
- Western Blot: use at 1-5 μg/mL.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL.
- 缓冲液
- PBS
- 注意事项
- Centrifuge vial prior to opening.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots.
- 有效期
- 24 months
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- 抗原
- ESM1 (Endothelial Cell-Specific Molecule 1 (ESM1))
- 别名
- Endocan/ESM-1 (ESM1 产品)
- 别名
- ESM1 antibody, zgc:153027 antibody, 0610042H23Rik antibody, AV004503 antibody, ESM-1 antibody, Pg25 antibody, endocan antibody, endothelial cell specific molecule 1 antibody, endothelial cell-specific molecule 1 antibody, ESM1 antibody, esm1 antibody, Esm1 antibody
- 背景
- Esm1, ESM-1, AV004503, 0610042H23Rik,Endocan (endothelial cell proteoglycan), also known as endothelialcell specific molecule1 (ESM-1), is a 50 kDa monomeric, secreted, cysteinerich proteoglycan identified initially in endothelial cells of the kidney and lung. Mouse Endocan is synthesized as a 184 amino acid (aa) precursor that contains a 21 aa signal sequence and a 20 kDa, 163 aa mature region. The N-terminal 2/3 of the molecule contains 18 cysteine residues and there are no potential N-linked glycosylation sites. Based on human Endocan, there are at least two potential O-linked glycosylation sites, one of which will likely be utilized on Ser at position # 136 of the mature molecule. The posttranslational modification is approximately 30 kDa in size. It consists of a single dermatan sulfate chain that contains 4O sulfated N-acetyl galactosamine with αiduronate. This chain is suggested to bind HGF and contribute to HGF mitogenic activity. Mature mouse Endocan shares 96 % and 74 % aa identity with rat and human Endocan, respectively. In human, there is a potential for an alternate splice variant. It shows a deletion of aa 82-131, a range which would not remove the dermatan sulfate attachment site. It is not known if such a splice form exists in mouse. Endocan is expressed by endothelial cells, adipocytes, bronchial epithelium and distal renal tubular epithelium. It is upregulated by TNFα and VEGF, and is known to bind to LFA1 (integrin αLβ2) on the surface of PBMCs, blocking LFA1 interaction with ICAM1. Normal circulating levels of Endocan are approximately 1 ng/mL.
- 基因ID
- 71690
- NCBI登录号
- NM_023612, NP_076101
- UniProt
- Q9QYY7
- 途径
- Growth Factor Binding
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