PDCD10 抗体
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- 抗原 See all PDCD10 抗体
- PDCD10 (Programmed Cell Death 10 (PDCD10))
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PDCD10 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF)
- 原理
- CCM-3 antibody
- 特异性
- Recombinant human CCM3
- 产品特性
- Chromosomal location: 3q26.1
- 纯化方法
- Protein A purified
- 免疫原
- Recombinant human CCM3 (ABIN1589742)
- 亚型
- IgG
- Top Product
- Discover our top product PDCD10 Primary Antibody
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anti-Programmed Cell Death 10 (PDCD10) antibody
PDCD10 适用: 人, 大鼠, 小鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Programmed Cell Death 10 (PDCD10) (AA 1-212) antibodyPDCD10 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Programmed Cell Death 10 (PDCD10) (Internal Region) antibodyPDCD10 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Programmed Cell Death 10 (PDCD10) (AA 145-212) antibodyPDCD10 适用: 大鼠 ELISA, IF (cc), IF (p), IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Programmed Cell Death 10 (PDCD10) (AA 103-212) antibodyPDCD10 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1B11 unconjugated
anti-Programmed Cell Death 10 (PDCD10) (AA 1-212) antibodyKO Validated PDCD10 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Programmed Cell Death 10 (PDCD10) (AA 1-212), (N-Term) antibodyPDCD10 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Western Blot: Use 1-5 μg/mL
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL.
- 缓冲液
- 0.5X PBS, pH 7.2
- 注意事项
- Centrifuge vial prior to opening. Avoid repeated freeze-thaw cycles.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots.
- 有效期
- 24 months
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- 抗原
- PDCD10 (Programmed Cell Death 10 (PDCD10))
- 别名
- CCM-3 (PDCD10 产品)
- 别名
- CCM3 antibody, TFAR15 antibody, 2410003B13Rik antibody, Ccm3 antibody, Tfa15 antibody, Tfar15 antibody, zgc:85629 antibody, ccm3a antibody, pdcd10 antibody, zgc:65826 antibody, programmed cell death 10 antibody, programmed cell death 10 S homeolog antibody, programmed cell death 10b antibody, programmed cell death 10a antibody, PDCD10 antibody, Pdcd10 antibody, pdcd10.S antibody, pdcd10b antibody, pdcd10a antibody
- 背景
- PDCD10, CCM3, TFAR15, programmed cell death 10,Cerebral cavernous malformations (CCMs) are sporadically acquired or inherited vascular lesions of the central nervous system consisting of clusters of dilated thin-walled blood vessels that predispose individuals to seizures and stroke. Mutations in CCM1, CCM2, or CCM3 lead to cerebral cavernous malformations, one of the most common hereditary vascular diseases of the brain. Endothelial cells within these lesions are the main disease compartments. Here, we show that adenoviral CCM3 expression inhibits endothelial cell migration, proliferation, and tube formation while down regulation of endogenous CCM3 results in increased formation of tube-like structures. Adenoviral CCM3 expression does not induce apoptosis under normal endothelial cell culture conditions but protects endothelial cells from staurosporine-induced cell death. Tyrosine kinase activity profiling suggests that CCM3 supports PDPK-1/Akt-mediated endothelial cell quiescence and survival (Schleider et al, Neurogenetics 12, 2011).
- 基因ID
- 11235
- NCBI登录号
- NM_007217, NP_009148
- UniProt
- Q9BUL8
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