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KDM5D 抗体

KDM5D 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN1589829
发货至: 中国
  • 抗原 See all KDM5D 抗体
    KDM5D (Lysine (K)-Specific Demethylase 5D (KDM5D))
    适用
    宿主
    • 11
    • 1
    克隆类型
    • 11
    • 1
    多克隆
    标记
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This KDM5D antibody is un-conjugated
    应用范围
    • 5
    • 3
    • 1
    • 1
    Western Blotting (WB)
    原理
    SMCY/JARID1D antibody
    特异性
    Recombinant human SMCY
    产品特性
    Chromosomal location: Yq11, Yq11
    纯化方法
    Protein A purified
    免疫原
    Recombinant human SMCY
    亚型
    IgG
    Top Product
    Discover our top product KDM5D Primary Antibody
  • 应用备注
    Western Blot: Use 1-5 μg/mL
    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL.
    缓冲液
    PBS
    注意事项
    Centrifuge vial prior to opening.
    储存条件
    4 °C,-20 °C
    储存方法
    The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots.
    有效期
    24 months
  • 抗原
    KDM5D (Lysine (K)-Specific Demethylase 5D (KDM5D))
    别名
    SMCY/JARID1D (KDM5D 产品)
    别名
    JARID1D antibody, Jarid1d antibody, DKFZp468I1010 antibody, HY antibody, HYA antibody, SMCY antibody, Smcy antibody, lysine demethylase 5D antibody, lysine (K)-specific demethylase 5D antibody, lysine demethylase 5C antibody, KDM5D antibody, Kdm5d antibody, KDM5C antibody
    背景
    KDM5D lysine (K)-specific demethylase 5D, HY, HYA,H-Y antigen is defined as a male histocompatibility antigen that causes rejection of male skin grafts by female recipients of the same inbred strain of rodents. Male-specific, or H-Y antigen(s), are also detected by cytotoxic T cells and antibodies. H-Y antigen appears to be an integral part of the membrane of most male cells. In addition, H-Y antibodies detect a soluble form of H-Y that is secreted by the testis. The gene (Smcy/SMCY) coding for H-Y antigen detected by T cells has been cloned. It is expressed ubiquitously in male mice and humans, and encodes an epitope that triggers a specific T-cell response in vitro. Additional epitopes coded for by different Y-chromosomal genes are probably required in vivo for the rejection of male grafts by female hosts. The molecular nature of H-Y antigen detected by antibodies on most male cells is not yet known. Testis-secreted, soluble H-Y antigen, however, was found to be identical to Müllerian-inhibiting substance (MIS). MIS cross-reacts with H-Y antibodies and identical findings were obtained for soluble H-Y antigen and MIS, i.e., secretion by testicular Sertoli and, to a lesser degree, ovarian cells, binding to a gonad-specific receptor, induction of gonadal sex reversal in vitro and, in cattle, in vivo. H-Y antisera also detect a molecule or molecules associated with the heterogametic sex in non-mammalian vertebrates. Molecular data on this antigen or antigens are not yet available.
    基因ID
    8284
    NCBI登录号
    NM_001146705, NP_001140177
    UniProt
    Q9BY66
    途径
    Warburg Effect
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