HSP27 抗体
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- 抗原 See all HSP27 抗体
- HSP27 (Heat Shock Protein 27 (HSP27))
- 适用
- 人, Cow, 小鼠, Pig, 大鼠, 哺乳动物
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宿主
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小鸡
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克隆类型
- 多克隆
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标记
- This HSP27 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)
- 纯化方法
- IgY preparation
- 亚型
- IgY
- Top Product
- Discover our top product HSP27 Primary Antibody
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anti-Heat Shock Protein 27 (HSP27) (AA 1-201) antibody
HSP27 适用: Cow WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Heat Shock Protein 27 (HSP27) (AA 2-205) antibodyHSP27 适用: 人 WB, IHC, ICC, IP 宿主: 小鼠 Monoclonal D2 unconjugated
anti-Heat Shock Protein 27 (HSP27) antibodyHSP27 适用: 人 WB, ICC, IP, ELISA, IHC (p), EIA, IHC (fro) 宿主: 小鼠 Monoclonal G3-1 unconjugated
anti-Heat Shock Protein 27 (HSP27) antibodyHSP27 适用: 人, Cow, 小鼠, Pig, 大鼠, 哺乳动物 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal 6H11 unconjugated
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- 应用备注
- The antibody solution can be used at dilutions of at least 1:2,000 in immunofluorescence experiments. In western blotting using chemiluminescence it can be used at dilutions of 1:5,000 or lower.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 20 mg/mL
- 缓冲液
- This antibody is an IgY prep at a total protein concentration of 20mg/mL. The preparation contains 10mM sodium azide as a preservative.
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store at 4°C short term or -20°C long term.
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- 抗原
- HSP27 (Heat Shock Protein 27 (HSP27))
- 别名
- Heat Shock Protein 27 HSP27 (HSP27 产品)
- 别名
- 27 antibody, 27K antibody, 28 antibody, CG4466 antibody, Dhsp27 antibody, DmHSP27 antibody, DmHsp27 antibody, Dmel\\CG4466 antibody, HSP27 antibody, HSP28 antibody, Hsp 27 antibody, Hsp28 antibody, anon-WO0140519.69 antibody, hsp 27 antibody, hsp-27 antibody, hsp26 antibody, hsp27 antibody, hsp27/26 antibody, hsp28 antibody, small hsp locus 67B antibody, Heat shock protein 27 antibody, heat shock protein 27 antibody, Hsp27 antibody, CpipJ_CPIJ005642 antibody
- 背景
- The heat shock proteins were discovered, as the name suggests, since they are heavily upregulated when cells are stressed by temperatures above the normal physiological range. They are expressed in unstressed cells also and have a normal function as chaperones, helping other proteins to fold correctly, and are required in much greater amounts if the cell or tissue is stressed by heat. The increased levels are generated transcriptionally under the influence of a powerful transcription factor, the heat shock factor 1 (HSF1). The different heat shock proteins were originally named based on their SDS-PAGE mobility, so HSP27 has an an apparent molecular weight of 27 kDa. It is an abundant protein even under non-stress conditions and frequently shows up as a major spot on 2 dimensional gels of cells or tissues. It is known to associate with a variety of other proteins such as actin, intermediate filament subunits and ubiquitin and is found both in the cytoplasm and the nucleus of cells. HSP27 can become heavily phosphorylated under the influence of multiple protein kinases particularly as a result of activation of the p38/SAPK pathway. Upregulation of this protein is protective against neurodegenerative diseases at least in certain mouse models. Point mutations in the HSP27 gene are associated with two neurological diseases, Charcot-Marie-Tooth disease type 2F and distal hereditary motor neuropathy IIB. These diseases are associated with axonal loss apparently following defects in the transport of neurofilaments. The HGNC name for this protein is HSBP1.
- 途径
- VEGF Signaling
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