SAG 抗体
-
- 抗原 See all SAG 抗体
- SAG (S-Antigen, Retina and Pineal Gland (Arrestin) (SAG))
-
适用
- 人, 小鼠, 大鼠, Cow, Pig
-
宿主
- 小鼠
-
克隆类型
- 单克隆
-
标记
- This SAG antibody is un-conjugated
-
应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- 纯化方法
- affinity purified antibody
- 克隆位点
- S128
- 亚型
- IgG1
- Top Product
- Discover our top product SAG Primary Antibody
-
anti-S-Antigen, Retina and Pineal Gland (Arrestin) (SAG) (AA 1-405) antibody
SAG 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-S-Antigen, Retina and Pineal Gland (Arrestin) (SAG) (AA 4-249) antibodySAG 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-S-Antigen, Retina and Pineal Gland (Arrestin) (SAG) antibodySAG 适用: 人, 大鼠, Cow, Pig WB, IF, ICC, IHC (fro) 宿主: 小鼠 Monoclonal PDS-1 unconjugated
anti-S-Antigen, Retina and Pineal Gland (Arrestin) (SAG) (Internal Region) antibodySAG 适用: 人, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-S-Antigen, Retina and Pineal Gland (Arrestin) (SAG) (AA 369-418) antibodySAG 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-S-Antigen, Retina and Pineal Gland (Arrestin) (SAG) (AA 273-307) antibodySAG 适用: 小鼠 WB 宿主: 兔 Polyclonal RB53546 unconjugated
anti-S-Antigen, Retina and Pineal Gland (Arrestin) (SAG) antibodySAG 适用: 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-S-Antigen, Retina and Pineal Gland (Arrestin) (SAG) (AA 1-405) antibodySAG 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-S-Antigen, Retina and Pineal Gland (Arrestin) (SAG) (AA 369-418), (pSer412) antibodySAG 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-S-Antigen, Retina and Pineal Gland (Arrestin) (SAG) (Internal Region) antibodySAG 适用: 人, 小鼠, 大鼠 WB, ELISA, IP 宿主: 山羊 Polyclonal unconjugated
-
- 应用备注
- Try at dilutions of ~1:1,000 for immunofluorescence. For western blots try at 1:5,000. A suitable control tissue is retinal homogenate. The arrestin protein runs at about ~48 kDa on SDS-PAGE gels.
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 浓度
- 1 mg/mL
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store at 4°C short term or -20°C long term.
-
- 抗原
- SAG (S-Antigen, Retina and Pineal Gland (Arrestin) (SAG))
- 别名
- Arrestin-1/ S-antigen (SAG 产品)
- 别名
- RP47 antibody, S-AG antibody, MGC75721 antibody, MGC84416 antibody, sag antibody, zgc:114197 antibody, SAGMR antibody, SANTI antibody, ARR antibody, sag1 antibody, A930001K18Rik antibody, Arr1 antibody, Irbp antibody, arrestin antibody, S-antigen visual arrestin antibody, S-antigen antibody, S-antigen; retina and pineal gland (arrestin) antibody, S-antigen; retina and pineal gland (arrestin) S homeolog antibody, S-antigen; retina and pineal gland (arrestin) b antibody, S-antigen, retina and pineal gland (arrestin) antibody, S-antigen; retina and pineal gland (arrestin) L homeolog antibody, SAG antibody, PF10_0343 antibody, sag antibody, sag.S antibody, sagb antibody, Sag antibody, sag.L antibody
- 背景
- The arrestin proteins are a family of regulators of cell signaling of G protein-coupled receptors (GPCR). Visual arrestin was first discovered as a result of the experimental model of human uveitis, an autoimmune disease of the eye. In this model, called experimental allergic uveitis, animals were injected with extracts made from the retina of the same species mixed with Freund's complete adjuvant. The animals mounted a strong immune response to the extract, and the antibody response was used to identify several immunogenic retinal proteins. One of these was called S-antigen, for soluble antigen. The protein was found to be abundant in retina, about 48 kDa in molecular weight, and localized in the outer segments of the photoreceptors. Several years later, Hermann K�hn and colleagues discovered that this protein binds to phosphorylated rhodopsin and prevents this protein from activating transducin. Transducin is a typical heterotrimeric G protein, composed of alpha, and beta,gamma, subunits. Rhodopsin phosphorylation is mediated by Rhodopsin kinase (a.k.a. GRK1), the prototypic member of a family of GPCR kinases. Since the S-antigen protein arrested the activity of rhodopsin it was renamed arrestin, and became the prototypic member of the arrestin protein family. Subsequently, Robert
- 途径
- Regulation of G-Protein Coupled Receptor Protein Signaling
-
