This antibody is purified through a protein A column, followed by peptide affinity purification.
免疫原
This SRGAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 469-497 amino acids from the Central region of human SRGAP1.
GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42.