This antibody is purified through a protein A column, followed by peptide affinity purification.
免疫原
This TNFRSF21 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 356-385 amino acids from the Central region of human TNFRSF21.
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB and MAPK8/JNK, and induce cell apoptosis. Through its death domain, this receptor interacts with TRADD protein, which is known to serve as an adaptor that mediates signal transduction of TNF-receptors. Knockout studies in mice suggested that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation.