This antibody is purified through a protein A column, followed by peptide affinity purification.
免疫原
This CARM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 347-375 amino acids from the Central region of human CARM1.
Protein arginine N-methyltransferases, such as CARM1, catalyze the transfer of a methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins to form methylated arginine derivatives and S-adenosyl-L-homocysteine. Protein arginine methylation has been implicated in signal transduction, metabolism of nascent pre-RNA, and transcriptional activation (Frankel et al., 2002 [PubMed 11724789]).