This antibody is purified through a protein A column, followed by peptide affinity purification.
免疫原
This SH3BGR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 149-177 amino acids from the Central region of human SH3BGR.
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背景
Proline-rich peptide sequences have been shown to play important roles in protein-protein interactions that occur in signal transduction pathways. SH3 domain binding glutamic acid-rich protein (SH3BGR), also designated 21-glutamic acid-rich protein (21-GARP), is a 239-amino acid protein differentially expressed in heart and skeletal muscle. Its proline-rich region contains the consensus sequence for an SH3-binding domain and its acidic C-terminal region contains a glutamic acid-rich domain which may assume a coiled-coil structure. SH3BGR may be part of a multimeric complex, as it contains 2 functional domains involved in protein-protein interactions.