This antibody is purified through a protein A column, followed by peptide affinity purification.
免疫原
This SIPA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 942-970 amino acids from the C-terminal region of human SIPA1.
The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date.