This antibody is purified through a protein A column, followed by peptide affinity purification.
免疫原
This PRICKLE1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 678-704 amino acids from the C-terminal region of human PRICKLE1.
This gene encodes a nuclear receptor that may be a negative regulator of the Wnt/beta-catenin signaling pathway. The encoded protein localizes to the nuclear membrane and has been implicated in the nuclear trafficking of the transcription repressors REST/NRSF and REST4. Mutations in this gene have been linked to progressive myoclonus epilepsy. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 3.