This antibody is purified through a protein A column, followed by peptide affinity purification.
免疫原
This PDLIM3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 329-355 amino acids from the C-terminal region of human PDLIM3.
The protein encoded by this gene contains a PDZ domain and a LIM domain, indicating that it may be involved in cytoskeletal assembly. In support of this, the encoded protein has been shown to bind the spectrin-like repeats of alpha-actinin-2 and to colocalize with alpha-actinin-2 at the Z lines of skeletal muscle. This gene is found near a region of chromosome 4 that has been implicated in facioscapulohumeral muscular dystrophy, but this gene does not appear to be involved in the disease. Two transcript variants encoding different isoforms have been found for this gene.