This antibody is purified through a protein A column, followed by peptide affinity purification.
免疫原
This Mouse Derl2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 191-219 amino acids from the C-terminal region of mouse Derl2.
Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate (By similarity).