This antibody is purified through a protein A column, followed by peptide affinity purification.
免疫原
This BRD4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1160-1188 amino acids from the C-terminal region of human BRD4.
The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15,19)(q13,p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described. [provided by RefSeq].