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BRCA1 抗体 (AA 120-220)

Name: BRCA1 抗体 (AA 120-220)
Brand: antibodies-online
SKU: ABIN1513831
Availability: OutOfStock

BRCA1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

Western blot analysis of extracts of various cell lines, using BRCA1 antibody. (BRCA1 抗体 (AA 120-220))

Immunofluorescence analysis of A549 cell using BRCA1 antibody. (BRCA1 抗体 (AA 120-220))

Immunohistochemistry of paraffin-embedded human prostate using BRCA1 antibody. (BRCA1 抗体 (AA 120-220))

IHC (p)

Immunohistochemistry of paraffin-embedded mouse brain using BRCA1 antibody. (BRCA1 抗体 (AA 120-220))

IHC (p)

Immunohistochemistry of paraffin-embedded human breast cancer using BRCA1 antibody. (BRCA1 抗体 (AA 120-220))

IHC (p)

Immunofluorescence analysis of A549 cells using BRCA1 antibody. (BRCA1 抗体 (AA 120-220))

9 images

(2 references)

产品编号 ABIN1513831

发货至: 中国

Datasheet as PDF

抗原 See all BRCA1 抗体

BRCA1 (Breast Cancer 1 (BRCA1))
抗原表位
22

21

15

15

12

12

10

10

8

7

6

6

5

4

4

3

3

3

3

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 120-220
适用
199

34

26

3

2

1

1

1
人
宿主
167

37

2
兔
Compatible Secondaries
克隆类型
171

35
多克隆
标记
93

17

10

7

5

5

5

5

5

5

3

3

3

3

3

3

3

3

3

3

3

2

2

2

2

2

2

2

2
This BRCA1 antibody is un-conjugated
应用范围
125

68

42

41

40

37

30

24

23

13

11

10

9

9

3

2

2

2

1

1
Western Blotting (WB), Immunohistochemistry (IHC)

序列

DEVSIIQSMG YRNRAKRLLQ SEPENPSLQE TSLSVQLSNL GTVRTLRTKQ RIQPQKTSVY IELGSDSSED TVNKATYCSV GDQELLQITP QGTRDEISLD S

交叉反应

人, 小鼠

产品特性

Polyclonal Antibodies

纯化方法

Affinity purification

免疫原

A synthetic peptide corresponding to a sequence within amino acids 120-220 of human BRCA1 (NP_009225.1).

亚型

IgG
anti-Breast Cancer 1 (BRCA1) (AA 19-83) antibody
BRCA1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Breast Cancer 1 (BRCA1) (pSer1423) antibody
BRCA1 适用: 人, 大鼠, 小鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Breast Cancer 1 (BRCA1) (AA 229-335) antibody
BRCA1 适用: 人 IHC, ELISA 宿主: 小鼠 Monoclonal 6C6D2 unconjugated

anti-Breast Cancer 1 (BRCA1) (AA 400-699) antibody
BRCA1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

anti-Breast Cancer 1 (BRCA1) (AA 1661-1863) antibody
BRCA1 适用: 人, 大鼠, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Breast Cancer 1 (BRCA1) (Ser184) antibody
BRCA1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Breast Cancer 1 (BRCA1) (Ser184), (Ser186) antibody
BRCA1 适用: 人, 大鼠 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-Breast Cancer 1 (BRCA1) (AA 445-620) antibody
BRCA1 适用: 人 IHC, ISt, StM 宿主: 小鼠 Monoclonal BRCA1-1398 unconjugated

anti-Breast Cancer 1 (BRCA1) (AA 400-699) antibody
BRCA1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Breast Cancer 1 (BRCA1) (AA 1314-1600), (AA 1314-1864) antibody
BRCA1 适用: 人 WB, IF, IP, FACS, ICC 宿主: 小鼠 Monoclonal RAY unconjugated

应用备注

WB,1:500 - 1:2000,IHC,1:50 - 1:200

限制

仅限研究用
状态

Liquid

缓冲液

PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid freeze / thaw cycles

储存条件

-20 °C

储存方法

Store at -20°C. Avoid freeze / thaw cycles.
Yin, Liu, Peng, Peng, Yu, Gao, Yuan, Zhu, Cao, He, Gong, Sun, Fan, Li: "PARP inhibitor veliparib and HDAC inhibitor SAHA synergistically co-target the UHRF1/BRCA1 DNA damage repair complex in prostate cancer cells." in: Journal of experimental & clinical cancer research : CR, Vol. 37, Issue 1, pp. 153, (2018) (PubMed).

Penn, Yang, Zong, Lim, Cole, Yang, Baker, Goonewardena, Buckanovich: "Therapeutic Impact of Nanoparticle Therapy Targeting Tumor-Associated Macrophages." in: Molecular cancer therapeutics, Vol. 17, Issue 1, pp. 96-106, (2018) (PubMed).
抗原

BRCA1 (Breast Cancer 1 (BRCA1))

别名

BRCA1 (BRCA1 产品)

别名

BRCAI antibody, BRCC1 antibody, BROVCA1 antibody, IRIS antibody, PNCA4 antibody, PPP1R53 antibody, PSCP antibody, RNF53 antibody, iris antibody, pscp antibody, brcai antibody, brcc1 antibody, rnf53 antibody, brca1 antibody, BRCA1 antibody, LOC100224649 antibody, BRCA1, DNA repair associated antibody, breast cancer 1 antibody, breast cancer 1, early onset antibody, breast cancer 1 L homeolog antibody, BRCA1 antibody, brca1 antibody, LOC755086 antibody, Brca1 antibody, brca1.L antibody

背景

This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40 % of inherited breast cancers and more than 80 % of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.,BRCA1,BRCAI,BRCC1,BROVCA1,FANCS,IRIS,PNCA4,PPP1R53,PSCP,RNF53,Epigenetics & Nuclear Signaling,DNA Damage & Repair,Cancer,Tumor suppressors,Cell Biology & Developmental Biology,Cell Cycle,Centrosome,G2/M DNA Damage Checkpoint,Ubiquitin,Ubiquitin-Proteasome Signaling Pathway,BRCA1

分子量

7 kDa/78-85 kDa/202-210 kDa

基因ID

672

UniProt

P38398

途径

Cell Division Cycle, DNA Damage Repair, Intracellular Steroid Hormone Receptor Signaling Pathway, Positive Regulation of Response to DNA Damage Stimulus