PIERCE1 antibody, RbEST47 antibody, Rbest47 antibody, chromosome 9 open reading frame 116 antibody, RIKEN cDNA 1700007K13 gene antibody, chromosome ssa24 open reading frame, human C9orf116 antibody, chromosome 11 open reading frame, human C9orf116 antibody, C9orf116 antibody, 1700007K13Rik antibody, cssa24h9orf116 antibody, C11H9orf116 antibody
背景
PIERCE1, also known as C9orf116, is an important p53 target gene contributing to normal DNA damage response and may play crucial roles in maintaining genomic integrity against genotoxic stresses, including UVC irradiation (1,2). PIERCE1 exists as two alternatively spliced isoforms and is predominantly expressed in human small cell lung cancer (3-4). PIERCE1 knockdown induces down-regulation of proapoptotic genes including Ei24, Apaf1 and PTEN, suggesting that PIERCE1 is a proapoptotic gene. It is helpful for in-depth understanding of p53 pathways and the design of new cancer therapies (1-3).Synonyms: Pierce1, p53-induced expression in RB-null cells protein 1