ECRG4 antibody, ecrg4 antibody, ecrg4-A antibody, Ecrg4 antibody, chromosome 2 open reading frame, human C2orf40 antibody, chromosome 13 open reading frame, human C2orf40 antibody, chromosome 11 open reading frame, human C2orf40 antibody, chromosome 2 open reading frame 40 antibody, chromosome 2 open reading frame 40 L homeolog antibody, RIKEN cDNA 1500015O10 gene antibody, similar to RIKEN cDNA 1500015O10 antibody, C2H2orf40 antibody, C13H2orf40 antibody, C11H2orf40 antibody, C2orf40 antibody, c2orf40.L antibody, 1500015O10Rik antibody, RGD1305645 antibody
背景
The esophageal cancer-related gene 4 (ECRG4), also known as Augurin, was identified through differential display screening between esophageal cancer and normal tissue. Hypermethylation of CpG sites in the ECRG4 promoter correlate with ECRG4 downregulation in numerous esophageal squamous cell carcinoma tissues.. In transfected cells, overexpression of ECRG4 induced G1 arrest, dephosphorylation of Rb and decreased expression of cyclins D1 and D3. Increased expression of ECRG4 in aged mouse brain is observed compared with young mouse brain. The increased ECRG4 level was accompanied by elevated senescence-associated acidic beta-galactosidase activity, suggesting that ECRG4 is involved in cellular differentiation and senescence.Synonyms: C2orf40, ECRG4