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- 抗原 See all PHLPP1 抗体
- PHLPP1 (PH Domain and Leucine Rich Repeat Protein Phosphatase 1 (PHLPP1))
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抗原表位
- N-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PHLPP1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Enzyme Immunoassay (EIA)
- 纯化方法
- Affinity chromatography purified via peptide column
- 免疫原
- PHLPP1 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of Human PHLPP1
- 亚型
- IgG
- Top Product
- Discover our top product PHLPP1 Primary Antibody
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anti-PH Domain and Leucine Rich Repeat Protein Phosphatase 1 (PHLPP1) (AA 1508-1717) antibody
PHLPP1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-PH Domain and Leucine Rich Repeat Protein Phosphatase 1 (PHLPP1) antibodyPHLPP1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-PH Domain and Leucine Rich Repeat Protein Phosphatase 1 (PHLPP1) (C-Term) antibodyPHLPP1 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-PH Domain and Leucine Rich Repeat Protein Phosphatase 1 (PHLPP1) (N-Term) antibodyPHLPP1 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-PH Domain and Leucine Rich Repeat Protein Phosphatase 1 (PHLPP1) antibodyPHLPP1 适用: 人, 小鼠, 大鼠 IF 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 浓度
- 1.0 mg/mL
- 缓冲液
- PBS containing 0.02 % Sodium Azide as preservative
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- 抗原
- PHLPP1 (PH Domain and Leucine Rich Repeat Protein Phosphatase 1 (PHLPP1))
- 别名
- PHLPP1 (PHLPP1 产品)
- 别名
- PHLPP antibody, PLEKHE1 antibody, SCOP antibody, AI836256 antibody, Phlpp antibody, Plekhe1 antibody, mKIAA0606 antibody, Scop antibody, PH domain and leucine rich repeat protein phosphatase 1 antibody, PHLPP1 antibody, phlpp1 antibody, Phlpp1 antibody
- 背景
- PHLPP1 is a member of the serine/threonine phosphatase family, which are important regulators of Akt serine-threonine kinases (AKT1, AKT2, AKT3) and conventional/novel protein kinase C (PKC) isoforms. PHLPP1 and PHLPP2 have a similar domain structure and have been shown to dephosphorylate and inactivate, distinct Akt isoforms, at one of the two critical phosphorylation sites required for activation: Serine473. PHLPP2 dephosphorylates AKT1 and AKT3, whereas PHLPP1 is specific for AKT2 and AKT3. PHLPP1 promotes apoptosis and may act as a tumor suppressor. Increased expression of PHLPP1 may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling.Synonyms: KIAA0606, PH domain leucine-rich repeat-containing protein phosphatase 1, PHLPP, PLEKHE1, Pleckstrin homology domain-containing family E member 1, SCOP, Suprachiasmatic nucleus circadian oscillatory protein
- 分子量
- 189 kDa
- 基因ID
- 23239
- NCBI登录号
- NP_919431
- 途径
- PI3K-Akt Signaling, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway
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