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PHLPP2 抗体 (C-Term)

PHLPP2 适用: 人 WB, EIA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN1449986
发货至: 中国
  • 抗原 See all PHLPP2 抗体
    PHLPP2 (PH Domain and Leucine Rich Repeat Protein Phosphatase 2 (PHLPP2))
    抗原表位
    • 8
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    C-Term
    适用
    • 16
    • 5
    • 2
    • 1
    • 1
    宿主
    • 15
    • 1
    克隆类型
    • 16
    多克隆
    标记
    • 16
    This PHLPP2 antibody is un-conjugated
    应用范围
    • 15
    • 7
    • 6
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    纯化方法
    Affinity chromatography purified via peptide column
    免疫原
    PHLPP2 antibody was raised against a 20 amino acid synthetic peptide near the carboxy terminus of human PHLPP2.
    亚型
    IgG
    Top Product
    Discover our top product PHLPP2 Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 浓度
    1.0 mg/mL
    缓冲液
    PBS containing 0.02 % Sodium Azide as preservative
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    -20 °C
    储存方法
    Store the antibody (in aliquots) at -20 °C.
  • 抗原
    PHLPP2 (PH Domain and Leucine Rich Repeat Protein Phosphatase 2 (PHLPP2))
    别名
    PHLPP2 (PHLPP2 产品)
    别名
    PHLPPL antibody, phlppl antibody, AI481772 antibody, C130044A18Rik antibody, Phlppl antibody, RGD1562857 antibody, PH domain and leucine rich repeat protein phosphatase 2 antibody, PH domain and leucine rich repeat protein phosphatase 2 S homeolog antibody, PHLPP2 antibody, phlpp2.S antibody, phlpp2 antibody, Phlpp2 antibody
    背景
    PHLPP2 is a member of the serine/threonine phosphatase family, which are important regulators of Akt serine-threonine kinases (AKT1, AKT2, AKT3) and conventional/novel protein kinase C (PKC) isoforms. PHLPP1 and PHLPP2 have a similar domain structure and have been shown to dephosphorylate and inactivate, distinct Akt isoforms, at one of the two critical phosphorylation sites required for activation: Serine473. PHLPP2 dephosphorylates AKT1 and AKT3, whereas PHLPP1 is specific for AKT2 and AKT3. PHLPP1 promotes apoptosis and may act as a tumor suppressor. PHLPP2 associates with and is inhibited by adenylyl cyclase type 6 (AC6), thereby allowing Akt activation .Synonyms: KIAA0931, PH domain leucine-rich repeat-containing protein phosphatase 2, PH domain leucine-rich repeat-containing protein phosphatase-like, PHLPP-like, PHLPPL
    分子量
    156 kDa
    基因ID
    23035
    NCBI登录号
    NP_055835
    途径
    PI3K-Akt Signaling, Fc-epsilon Receptor Signaling Pathway
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