cb212 antibody, prc1 antibody, prc1l antibody, zgc:55982 antibody, zgc:86918 antibody, MGC68845 antibody, zgc:55664 antibody, ase1 antibody, ASE1 antibody, D7Ertd348e antibody, protein regulator of cytokinesis 1 antibody, protein regulator of cytokinesis 1a antibody, protein regulator of cytokinesis 1 S homeolog antibody, protein regulator of cytokinesis 1b antibody, PRC1 antibody, prc1a antibody, prc1.S antibody, prc1b antibody, CNC07120 antibody, prc1 antibody, Prc1 antibody
背景
PRC1 (Protein Regulator of Cytokinesis 1) is a key regulator of cytokinesis and has been identified as a substrate for several cyclin-dependent kinases (CDKs). High levels of PRC1 expression occurs during S and G2/M and drops dramatically after mitosis exit and G1 entry. It is located in the nucleus during interphase and binds to the midzone of mitotic spindles during anaphase and is localized to the cell midbody during cytokinesis. Depletion of PRC1 has been shown to prevent cellular cleavage, but it has no effect on nuclear division, demonstrating the importance of PRC1 in mitosis.Synonyms: ASE1, Protein regulator of cytokinesis 1