ARNTL2
适用: 人
WB, IF (cc), IF (p)
宿主: 兔
Polyclonal
AbBy Fluor® 555
应用备注
Optimal working dilution should be determined by the investigator.
限制
仅限研究用
溶解方式
Add 50 μL of distilled water to a final concentration of 1 mg/mL.
注意事项
Avoid repeated freezing and thawing.
储存条件
4 °C/-20 °C
储存方法
Store lyophilized at 2-8 °C for one month or at -20 °C long term. After reconstitution store the antibody undiluted at 2-8 °C for up to one month or in aliquots at -20 °C long term.
ARNTL2-CLOCK heterodimers activate E-box element (3'-CACGTG-5') transcription. Also, in umbilical vein endothelial cells, ARNTL2 activates SERPINE1 through E-box sites. This transactivation is inhibited by PER2 and CRY1. It is xxpressed in fetal brain and highly expressed in brain and placenta. Lower levels are found in heart, liver, thymus, kidney and lung. It is located to endothelial cells and neuronal cells of the suprachiasmatic nucleus (SCN) and also detected in endothelial cells of the heart, lung and kidney. In the brain, it is specifically expressed in the thalamus, hippocampus and amygdala.Synonyms: Aryl hydrocarbon receptor nuclear translocator-like protein 2, BHLHE6, Basic-helix-loop-helix-PAS protein MOP9, Brain and muscle ARNT-like 2, CLIF, CYCLE-like factor, Class E basic helix-loop-helix protein 6, MOP9, Member of PAS protein 9, PAS domain-containing protein 9, PASD9, bHLHe6