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SQSTM1 抗体 (C-Term)

SQSTM1 适用: 人 WB, IF, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN1449619
发货至: 中国
  • 抗原 See all SQSTM1 抗体
    SQSTM1 (Sequestosome 1 (SQSTM1))
    抗原表位
    • 18
    • 17
    • 15
    • 13
    • 8
    • 7
    • 7
    • 7
    • 7
    • 6
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    • 5
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    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 324-353, C-Term
    适用
    • 149
    • 65
    • 61
    • 18
    • 4
    • 4
    • 4
    • 4
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    • 2
    • 2
    • 2
    • 1
    • 1
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    宿主
    • 125
    • 22
    • 1
    • 1
    克隆类型
    • 127
    • 22
    多克隆
    标记
    • 70
    • 11
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    This SQSTM1 antibody is un-conjugated
    应用范围
    • 100
    • 56
    • 39
    • 37
    • 20
    • 16
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    • 9
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    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    纯化方法
    Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
    免疫原
    KLH conjugated synthetic peptide between 324~353 amino acids from the C-terminal region of Human SQSTM1
    亚型
    Ig Fraction
    Top Product
    Discover our top product SQSTM1 Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    0.25 mg/mL
    缓冲液
    PBS containing 0.09 % (W/V) Sodium Azide as preservative
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • 抗原
    SQSTM1 (Sequestosome 1 (SQSTM1))
    别名
    SQSTM1 (SQSTM1 产品)
    别名
    SQSTM1 antibody, sqstm1 antibody, MGC79491 antibody, A170 antibody, OSIL antibody, PDB3 antibody, ZIP3 antibody, p60 antibody, p62 antibody, p62B antibody, OSF-6 antibody, Osi antibody, STAP antibody, ZIP antibody, sb:cb621 antibody, zgc:85784 antibody, sequestosome 1 antibody, sequestosome 1 L homeolog antibody, SQSTM1 antibody, sqstm1 antibody, Sqstm1 antibody, sqstm1.L antibody
    背景
    SQSTM1/p62 is an adapter protein which binds ubiquitin and may regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. This protein may play a role in titin/TTN downstream signaling in muscle cells, and may also regulate signaling cascades through ubiquitination. This protein is involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. SQSTM1/p62 also appears to play a role in macroautophagic removal of intracellular protein aggregates. Cellular depletion studies of SQSTM1/p62 have indicated a role for association with LC3 and aggregate proteins in order to facilitate normal formation of the autophagosome.Synonyms: EBI3-associated protein of 60 kDa, EBIAP, ORCA, OSIL, Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa, Sequestosome-1, Ubiquitin-binding protein p62, p60, p62
    分子量
    47687 Da
    基因ID
    8878
    NCBI登录号
    NP_001135770
    途径
    NF-kappaB Signaling, Neurotrophin Signaling Pathway, Autophagy
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