PIK3C3 抗体 (AA 19-49)
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- 抗原 See all PIK3C3 抗体
- PIK3C3 (Phosphoinositide-3-Kinase, Class 3 (PIK3C3))
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抗原表位
- AA 19-49
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PIK3C3 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
- 纯化方法
- Protein A column, followed by peptide affinity purification.
- 免疫原
- KLH conjugated synthetic peptide between 19~49 amino acids surrounding Serine 34 of Human PI3KC3
- 亚型
- Ig Fraction
- Top Product
- Discover our top product PIK3C3 Primary Antibody
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.25 mg/mL
- 缓冲液
- PBS containing 0.09 % (W/V) Sodium Azide as preservative
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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Generation of human endometrial knockout cell lines with the CRISPR/Cas9 system confirms the prostaglandin F2α synthase activity of aldo-ketoreductase 1B1." in: Molecular human reproduction, Vol. 20, Issue 7, pp. 650-63, (2015) (PubMed).
: "Indoleamine 2,3-dioxygenase depletes tryptophan, activates general control non-derepressible 2 kinase and down-regulates key enzymes involved in fatty acid synthesis in primary human CD4+ T cells." in: Immunology, Vol. 146, Issue 2, pp. 292-300, (2015) (PubMed).
: "Crucial roles of the protein kinases MK2 and MK3 in a mouse model of glomerulonephritis." in: PLoS ONE, Vol. 8, Issue 1, pp. e54239, (2013) (PubMed).
: "Membrane phospholipid metabolism during phagocytosis in human neutrophils." in: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 15, Issue 5, pp. 409-24, (2010) (PubMed).
: "Identification of a novel putative pancreatic stem/progenitor cell marker DCAMKL-1 in normal mouse pancreas." in: American journal of physiology. Gastrointestinal and liver physiology, Vol. 299, Issue 2, pp. G303-10, (2010) (PubMed).
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Generation of human endometrial knockout cell lines with the CRISPR/Cas9 system confirms the prostaglandin F2α synthase activity of aldo-ketoreductase 1B1." in: Molecular human reproduction, Vol. 20, Issue 7, pp. 650-63, (2015) (PubMed).
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- 抗原
- PIK3C3 (Phosphoinositide-3-Kinase, Class 3 (PIK3C3))
- 别名
- PIK3C3 (PIK3C3 产品)
- 别名
- im:7147158 antibody, wu:fc13g06 antibody, wu:fz51e12 antibody, zgc:112016 antibody, zgc:113009 antibody, VPS34 antibody, hVps34 antibody, 5330434F23Rik antibody, Vps34 antibody, phosphatidylinositol 3-kinase catalytic subunit type 3 antibody, phosphatidylinositol 3-kinase catalytic subunit type 3 L homeolog antibody, phosphatidylinositol 3-kinase, catalytic subunit type 3 antibody, PIK3C3 antibody, pik3c3.L antibody, pik3c3 antibody, Pik3c3 antibody
- 背景
- PI3KC3 is a catalytic subunit of the PI3K complex involved in the transport of lysosomal enzyme precursors to lysosomes. This enzyme acts catalytically to convert 1-phosphatidyl-1D-myo-inositol to 1-phosphatidyl-1D-myo-inositol 3-phosphate. Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). The regulation of the Beclin 1-PI3KC3 complex lipid kinase activity is a critical element in the autophagy signaling pathway.Synonyms: PI3-kinase type 3, PI3K type 3, Phosphatidylinositol 3-kinase catalytic subunit type 3, Phosphoinositide-3-kinase class 3, VPS34
- 分子量
- 101549 Da
- 基因ID
- 5289
- NCBI登录号
- NP_002638
- 途径
- AMPK Signaling, Activation of Innate immune Response, Inositol Metabolic Process, Toll-Like Receptors Cascades, Autophagy
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