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Transferrin Receptor 抗体 (FITC)

TFRC 适用: 人 FACS 宿主: 小鼠 Monoclonal WK7 FITC
产品编号 ABIN1449272
发货至: 中国
  • 抗原 See all Transferrin Receptor (TFRC) 抗体
    Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))
    适用
    • 194
    • 84
    • 30
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    • 1
    宿主
    • 111
    • 110
    • 30
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    小鼠
    克隆类型
    • 155
    • 94
    • 3
    单克隆
    标记
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    This Transferrin Receptor antibody is conjugated to FITC
    应用范围
    • 145
    • 133
    • 66
    • 66
    • 56
    • 38
    • 25
    • 23
    • 18
    • 12
    • 7
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    • 1
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    Flow Cytometry (FACS)
    纯化方法
    Protein A agarose
    免疫原
    Human myeloma cell line (RPMI8226)
    克隆位点
    WK7
    亚型
    IgG1
    Top Product
    Discover our top product TFRC Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    0.5 mg/mL
    缓冲液
    PBS containing 1 % BSA and 0.09 % NaN3
    储存条件
    4 °C
    储存方法
    Store at 2-8 °C.
  • 抗原
    Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))
    别名
    CD71 / TFRC (TFRC 产品)
    背景
    CD71 is a homodimeric type II transmembrane glycoprotein consisting of two disulfide-bonded 95 kDa chains. CD71 is the transferrin receptor (TfR). The CD71 binds iron saturated holo-transferrin on the cell surface and is internalized and transported to early sorting endosomes, where the complexed iron is rapidly separated from transferrin. Subsequently, the CD71-transferrin complex accumulates within recycling endosomes and then recycles to the plasma membrane. On the cell surface, iron-free apotransferrin has negligible affinity for CD71, and is released from the cell, ready to begin a new cycle. CD 71 is expressed on activated B and T cells, macrophages, reticulocytes, erythroid precursors, and malignant tissues. Particularly high expression of CD71 is reported in the reticulocytes and erythroid series, reflecting the requirement for iron in hemoglobin. CD71 expression is upregulated on immature proliferating cells and low levels on resting mature lymphocytes. In addition to this general function, CD71 appears to play a costimulatory role in T cell activation and receptor for IgA1 antibodies.Synonyms: TfR1, Transferrin receptor protein 1, p90
    基因ID
    9606
    UniProt
    P02786
    途径
    Transition Metal Ion Homeostasis
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