MDM4-binding Protein 抗体 (pSer367)
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- 抗原 See all MDM4-binding Protein (MDM4) 抗体
- MDM4-binding Protein (MDM4) (Mdm4-binding Protein (MDM4))
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抗原表位
- pSer367
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适用
- 人, 小鼠
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This MDM4-binding Protein antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 特异性
- This antibody specifically recognizes MdmX protein phosphorylated at Ser367.
- 交叉反应 (详细)
- Species reactivity (tested):Human, Mouse
- 克隆位点
- #15
- 亚型
- IgG2b
- Top Product
- Discover our top product MDM4 Primary Antibody
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 浓度
- 1.0 mg/mL
- 缓冲液
- PBS containing 50 % glycerol, pH 7.2. No preservative is contained.
- 储存液
- Without preservative
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- -20 °C
- 储存方法
- Upon receipt, store (in aliqouts) at -20 °C.
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- 抗原
- MDM4-binding Protein (MDM4) (Mdm4-binding Protein (MDM4))
- 别名
- MDM4 (MDM4 产品)
- 别名
- mdmx antibody, HDMX antibody, MDMX antibody, MRP1 antibody, wu:fa09h09 antibody, wu:fi33d10 antibody, 4933417N07Rik antibody, AA414968 antibody, AL023055 antibody, AU018793 antibody, AU021806 antibody, C85810 antibody, Mdmx antibody, MDM4, p53 regulator S homeolog antibody, MDM4, p53 regulator antibody, transformed mouse 3T3 cell double minute 4 antibody, mdm4.S antibody, MDM4 antibody, Mdm4 antibody, mdm4 antibody
- 背景
- MdmX (Mdm4, HdmX) inhibits p53-and p73-dependent cell cycle arrest and apoptosis by binding to the transcription activation domains of these proteins. MdmX consists of 490 amino acids with the molecular weight of 54,864 and contains a RIING-finger domain and a nuclear transport signal. It is known that the protein migrates aberrantly in SDS-PAGE at the position of an 80 kDa protein. MdmX is phosphorylated at Ser367 by Chk2 kinase downstream of ATM in response to DNA damage, and as the result, it binds to 14-3-3 and is transported into nucleus where it is degraded by Mdm2. This process activates the p53 functions (Ref 1, 2, 3).Synonyms: Double minute 4 protein, MDM-4, MDMX, Mdm2-like p53-binding protein, p53-binding protein Mdm4
- 基因ID
- 4194
- NCBI登录号
- NP_002384
- UniProt
- O15151
- 途径
- Cell Division Cycle
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