TLR4 抗体
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- 抗原 See all TLR4 抗体
- TLR4 (Toll-Like Receptor 4 (TLR4))
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适用
- 小鼠
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This TLR4 antibody is un-conjugated
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应用范围
- Flow Cytometry (FACS), Immunoprecipitation (IP)
- 特异性
- This antibody reacts with mouse TLR4 but doesn't react with mouse MD-2 on flow cytometry.
- 纯化方法
- Protein A agarose
- 免疫原
- Mouse TLR4-MD-2 transfected Ba/F3 cell
- 克隆位点
- UT49
- 亚型
- IgG2b
- Top Product
- Discover our top product TLR4 Primary Antibody
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 浓度
- 1.0 mg/mL
- 缓冲液
- PBS containing 50 % glycerol, pH 7.2. Contains no preservatives.
- 储存液
- Without preservative
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- -20 °C
- 储存方法
- Upon receipt, store (in aliqouts) at -20 °C.
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- 抗原
- TLR4 (Toll-Like Receptor 4 (TLR4))
- 别名
- CD284 / TLR4 (TLR4 产品)
- 背景
- Toll, a Drosophila receptor molecule with extracellular leucine-rich repeat (LRR), has a role in triggering innate defenses against bacteria or fungi. TLR4 (Toll-like receptor 4) is a member of TLR family, which is human homologue of Toll protein. It has extracellular LRR and an intracellular signaling domain, which is similar to the type I IL-1 receptor. TLR4 is expressed in subpopulations of cells including myeloid cells, B-cells, monocytes, and endothelial cells. Recent studies have suggested that TLR4 might act as a receptor for LPS (lipopolysaccharide). TLR4 alone is not capable of sensing and signaling the presence of LPS, but another molecule MD-2, which is physically associated with TLR4, is required for LPS recognition through TLR4.Synonyms: Toll-like receptor 4
- 基因ID
- 21898
- NCBI登录号
- NP_067272
- UniProt
- Q9QUK6
- 途径
- TLR signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades, Inflammasome, S100 Proteins
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