ES1 Protein Homolog (AA 1-281), (full length), (N-Term) 抗体
适用: 大鼠
IF, IHC (p), IP, WB
宿主: 大鼠
Monoclonal
NM1
unconjugated
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- 抗原
- ES1 Protein Homolog
- 抗原表位
- AA 1-281, full length, N-Term
- 适用
- 大鼠
- 宿主
- 大鼠
- 克隆类型
- 单克隆
- 应用范围
- Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
- 特异性
- This antibody reacts with rat HES1.
- 纯化方法
- Protein G agarose
- 免疫原
- Full-length rat HES1 (1-281 aa)
- 克隆位点
- NM1
- 亚型
- IgG2a
-
- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
-
- 浓度
- 1.0 mg/mL
- 缓冲液
- PBS containing 50 % glycerol, pH 7.2. No preservative is contained.
- 储存液
- Without preservative
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- 抗原
- ES1 Protein Homolog
- 背景
- Two transcription factors with a helix-loop-helix motif, human achaete-scute homologue-1 (hASH1) and hairy/enhancer of split homologue-1 (HES1), are essential for proper neuronal development. hASH1 is constitutively expressed in the most virulent human lung cancer, small cell lung cancer (SCLC), which exhibits neuroendocrine (NE) features. Moreover, hASH1 is essential for development of normal pulmonary NE cells that resemble SCLC. HES1 acts to transcriptionally repress hASH1 expression. The repressive effect of HES1 is mediated by binding of the protein to a class C site in the hASH1 promoter. HES1 also plays a role in mid- and hindbrain development, and in Notch signaling in thymocytes.Synonyms: C21orf33, HES1, KNPI, Protein GT335, Protein KNP-I
- 基因ID
- 294326
- NCBI登录号
- NP_001004225
- UniProt
- P56571
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