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Connexin 43/GJA1 抗体 (C-Term)

GJA1 适用: 人, 大鼠, 小鼠, 犬, 猴, Cow, 兔, 小鸡, 豚鼠, Pig, 马, 绵羊, Hamster, 山羊, Avian, Cat, 驴 WB, IF, IHC (p), IHC (fro) 宿主: 山羊 Polyclonal unconjugated
产品编号 ABIN1440034
发货至: 中国
  • 抗原 See all Connexin 43/GJA1 (GJA1) 抗体
    Connexin 43/GJA1 (GJA1) (Gap Junction Protein, alpha 1, 43kDa (GJA1))
    抗原表位
    • 19
    • 16
    • 11
    • 8
    • 8
    • 7
    • 7
    • 7
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    • 4
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    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
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    C-Term
    适用
    • 124
    • 87
    • 82
    • 30
    • 10
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    • 8
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    • 6
    • 6
    • 5
    • 3
    • 3
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    • 1
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    • 1
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    • 1
    人, 大鼠, 小鼠, 犬, 猴, Cow, 兔, 小鸡, 豚鼠, Pig, 马, 绵羊, Hamster, 山羊, Avian, Cat, 驴
    宿主
    • 124
    • 6
    • 2
    • 1
    山羊
    克隆类型
    • 126
    • 6
    多克隆
    标记
    • 77
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Connexin 43/GJA1 antibody is un-conjugated
    应用范围
    • 91
    • 52
    • 46
    • 21
    • 19
    • 16
    • 13
    • 13
    • 10
    • 9
    • 6
    • 5
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    特异性
    Detects endogenous levels of total connexin 43.
    产品特性
    Gap junction protein, alpha 1, 43  kDa
    纯化方法
    epitope affinity purified
    免疫原
    Purified recombinant peptide derived from within residues 230 aa to the C-terminus of rat CX43 produced in E. coli.
    亚型
    IgG
  • 限制
    仅限研究用
  • 浓度
    4 mg/mL
    缓冲液
    Polyclonal antibody supplied as a 200 µL (4 mg/mL) aliquot in PBS, 20 % glycerol and 0.05 % sodium azide
    注意事项
    The antibody solution should be gently mixed before use.
    储存条件
    4 °C,-20 °C
    储存方法
    For continuous use, store at 2-8 deg,C for one-two days. For extended storage, store in -20 deg,C freezer. Working dilution samples should be discarded if not used within 12 hours.
  • Martins-Marques, Pinho, Zuzarte, Oliveira, Pereira, Sluijter, Gomes, Girao: "Presence of Cx43 in extracellular vesicles reduces the cardiotoxicity of the anti-tumour therapeutic approach with doxorubicin." in: Journal of extracellular vesicles, Vol. 5, pp. 32538, (2016) (PubMed).

    Martins-Marques, Anjo, Pereira, Manadas, Girão: "Interacting Network of the Gap Junction (GJ) Protein Connexin43 (Cx43) is Modulated by Ischemia and Reperfusion in the Heart." in: Molecular & cellular proteomics : MCP, Vol. 14, Issue 11, pp. 3040-55, (2016) (PubMed).

    Ribeiro-Rodrigues, Catarino, Marques, Ferreira, Martins-Marques, Pereira, Girão: "AMSH-mediated deubiquitination of Cx43 regulates internalization and degradation of gap junctions." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 28, Issue 11, pp. 4629-41, (2015) (PubMed).

  • 抗原
    Connexin 43/GJA1 (GJA1) (Gap Junction Protein, alpha 1, 43kDa (GJA1))
    别名
    CX43 (GJA1 产品)
    背景
    Cx43 is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. This protein is the major protein of gap junctions in embryonic development and in the heart that are thought to have a crucial role in the synchronized contraction of the heart.
    Synonyms: AVSD3, CX43, DFNB38, gap junction protein, alpha 1, 43kDa, GJA1, GJAL HSS, HLHS1, ODDD antibody.
    Ensembl identifier: ENSG00000152661
    途径
    MAPK Pathway, Myometrial Relaxation and Contraction, Cell-Cell Junction Organization
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