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Coagulation Factor VIII-Associated 1 (F8A1) (AA 2-80) 抗体 (Cy3)

F8A1 适用: 人 WB, IF (cc), IF (p) 宿主: 兔 Polyclonal Cy3
产品编号 ABIN1410687
发货至: 中国
  • 抗原 See all Coagulation Factor VIII-Associated 1 (F8A1) 抗体
    Coagulation Factor VIII-Associated 1 (F8A1)
    抗原表位
    • 14
    • 1
    • 1
    • 1
    • 1
    AA 2-80
    适用
    • 18
    • 3
    • 1
    宿主
    • 20
    克隆类型
    • 20
    多克隆
    标记
    • 7
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cy3
    应用范围
    • 20
    • 12
    • 12
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    预测反应
    Human,Mouse,Rat,Cow
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic peptide derived from human HAP40
    亚型
    IgG
    Top Product
    Discover our top product F8A1 Primary Antibody
  • 应用备注
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    有效期
    12 months
  • 抗原
    Coagulation Factor VIII-Associated 1 (F8A1)
    别名
    HAP40/F8a (F8A1 产品)
    别名
    DXS522E antibody, F8A antibody, HAP40 antibody, F8a antibody, Hap40 antibody, RGD1566014 antibody, f8a antibody, f8a1 antibody, hap40 antibody, dxs522e antibody, MGC147036 antibody, coagulation factor VIII associated 1 antibody, coagulation factor VIII-associated 1 antibody, coagulation factor VIII antibody, F8A1 antibody, F8a1 antibody, f8a1 antibody
    背景

    Synonyms: Coagulation factor 8 associated intronic transcript 1, Coagulation factor VIII associated intronic transcript 1, CpG island protein, DXS522E, F8a, F8A1, F8A2, F8A3, Factor 8 associated protein, Factor 8 intron 22 protein, Factor VIII associated protein, Factor VIII intron 22 protein, huntingtin associated protein 40, F8I2_HUMAN.

    Background: The Huntingtin protein contains a polyglutamine region, which leads to Huntingtin?s disease (HD) when the number of glutamine repeats exceeds thirty-five. The mutated Huntingtin protein acts within the nucleus to induce neurodegeneration by a cell-specific apoptotic mechanism. The loss of activity of the Huntingtin protein may be contributed to abnormal interactions between the mutant protein and other associated cellular proteins. Huntingtin interacts with a variety of proteins including HAP1, glyceraldehyde phosphate dehydrogenase (GAPDH), HAP40, Rab5 and HIP1. HAP40 mediates the recruitment of Huntingtin by Rab5 onto early endosomes. Specifically, this complex regulates endosome motility, which may be a key event of the pathogenetic process leading to neurodegeneration in HD.

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