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ALAS1 抗体 (Biotin)

ALAS1 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal Biotin
产品编号 ABIN1403245
发货至: 中国
  • 抗原 See all ALAS1 抗体
    ALAS1 (Aminolevulinate, delta-, Synthase 1 (ALAS1))
    适用
    • 50
    • 22
    • 20
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠
    宿主
    • 48
    • 2
    克隆类型
    • 39
    • 11
    多克隆
    标记
    • 20
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ALAS1 antibody is conjugated to Biotin
    应用范围
    • 30
    • 13
    • 9
    • 6
    • 5
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    交叉反应
    人, 小鼠, 大鼠
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic peptide derived from human ALAS1/ALAS-H
    亚型
    IgG
    Top Product
    Discover our top product ALAS1 Primary Antibody
  • 应用备注
    WB 1:300-5000
    IHC-P 1:200-400
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C for 12 months.
    有效期
    12 months
  • 抗原
    ALAS1 (Aminolevulinate, delta-, Synthase 1 (ALAS1))
    别名
    ALAS1 (ALAS1 产品)
    别名
    ALAS antibody, ALAS3 antibody, ALASH antibody, MIG4 antibody, ALAS-N antibody, Alas-1 antibody, Alas-h antibody, ALAS-H antibody, ALASN antibody, ALAS1 antibody, wu:fb58d01 antibody, wu:fi12g09 antibody, 5'-aminolevulinate synthase 1 antibody, aminolevulinic acid synthase 1 antibody, alanyl-tRNA synthetase protein antibody, aminolevulinate, delta-, synthase 1 antibody, ALAS1 antibody, Alas1 antibody, alas1 antibody, alas1.S antibody, alaS1 antibody
    背景

    Synonyms: mitochondrial, nonspecic, 5 aminolevulinate synthase, 5 aminolevulinate synthase nonspecic mitochondrial, 5 aminolevulinic acid synthase, 5-aminolevulinate synthase, 5-aminolevulinic acid synthase 1, Alas 1, ALAS 3, ALAS, ALAS H, ALAS N, ALAS-H, alaS1, ALAS3, ALASH, Aminolevulinate delta synthase 1, Aminolevulinic acid synthase 1, Delta ALA synthetase, Delta aminolevulinate synthase, Delta-ALA synthase 1, Delta-aminolevulinate synthase 1, HEM1_HUMAN, MIG 4, MIG4, Migration inducing protein 4.

    Background: 5-aminolevulinate synthase 1 (ALAS-H) and 2 (ALAS-E) are two isoforms of ALAS, an enzyme catalyzing the first step of the heme biosynthetic pathway in mammals. The erythroid-specific isoenzyme, ALAS-E, regulates the first step of hematopoietic cell differentation and iron metabolism in the liver. ALAS-H is a housekeeping protein which mediates synthesis of early heme in the mitochondria of most cells. Succinyl CoA associates with ALAS-E in protein conformation change and translocation of ALAS-E into the mitochondria and does not interact with ALAS-H. The ALAS-E 5'-flanking region contains binding sites for nuclear activators such as GATA-1, NF-E2 and EKLF. Since the ALAS gene maps to the X chromosome, mutation of the gene leads to the pyridoxine-refractory X-linked sideroblastic anemia.

    基因ID
    211
    途径
    Regulation of Lipid Metabolism by PPARalpha
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