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Cullin 7 抗体 (AbBy Fluor® 488)

CUL7 适用: 人, 小鼠, 大鼠 WB, IF (p) 宿主: 兔 Polyclonal AbBy Fluor® 488
产品编号 ABIN1400986
发货至: 中国
  • 抗原 See all Cullin 7 (CUL7) 抗体
    Cullin 7 (CUL7)
    适用
    • 41
    • 22
    • 20
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠
    宿主
    • 40
    • 1
    克隆类型
    • 40
    • 1
    多克隆
    标记
    • 15
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    This Cullin 7 antibody is conjugated to AbBy Fluor® 488
    应用范围
    • 27
    • 12
    • 8
    • 5
    • 4
    • 4
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    交叉反应
    人, 小鼠, 大鼠
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic peptide derived from human Cullin 7
    亚型
    IgG
    Top Product
    Discover our top product CUL7 Primary Antibody
  • 应用备注
    IF(IHC-P) 1:50-200
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    有效期
    12 months
  • 抗原
    Cullin 7 (CUL7)
    别名
    Cullin 7 (CUL7 产品)
    别名
    cullin-7 antibody, CUL7 antibody, Cullin-7 antibody, KIAA0076 antibody, dJ20C7.5 antibody, 2510004L20Rik antibody, AA409809 antibody, C230011P08Rik antibody, p185 antibody, p193 antibody, cullin 7 antibody, CUL7 antibody, Cul7 antibody
    背景

    Synonyms: CUL-7, CUL7, CUL7_HUMAN, Cullin-7, dJ20C7.5, KIAA0076.

    Background: Component of a probable SCF-like E3 ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably plays a role in the degradation of proteins involved in endothelial proliferation and/or differentiation (By similarity). Seems not to promote polyubiquitination and proteasomal degradation of TP53. In vitro, complexes of CUL7 with either CUL9 or FBXW8 or TP53 contain E3 ubiquitin-protein ligase activity.Involvement in disease: Defects in CUL7 are the cause of 3M syndrome type 1 (3M1). An autosomal recessive disorder characterized by severe pre- and postnatal growth retardation, facial dysmorphism, large head circumference, and normal intelligence and endocrine function. Skeletal changes include long slender tubular bones and tall vertebral bodies.

    基因ID
    9820
    途径
    ER-Nucleus Signaling
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