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Glutathione Synthetase 抗体 (AA 81-160) (Biotin)

GSS 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal Biotin
产品编号 ABIN1393693
发货至: 中国
  • 抗原 See all Glutathione Synthetase (GSS) 抗体
    Glutathione Synthetase (GSS)
    抗原表位
    • 9
    • 8
    • 7
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 81-160
    适用
    • 71
    • 41
    • 36
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠
    宿主
    • 65
    • 9
    克隆类型
    • 57
    • 17
    多克隆
    标记
    • 29
    • 6
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Glutathione Synthetase antibody is conjugated to Biotin
    应用范围
    • 50
    • 22
    • 13
    • 9
    • 9
    • 6
    • 6
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    交叉反应
    人, 小鼠, 大鼠
    预测反应
    Dog,Cow,Sheep,Pig,Horse
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic peptide derived from human Glutathione Syntase
    亚型
    IgG
    Top Product
    Discover our top product GSS Primary Antibody
  • 应用备注
    WB 1:300-5000
    IHC-P 1:200-400
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C for 12 months.
    有效期
    12 months
  • 抗原
    Glutathione Synthetase (GSS)
    别名
    GSS/Glutathione Synthetase (GSS 产品)
    别名
    PRNP antibody, 6835 antibody, CG32497 antibody, CG33065 antibody, CG6835 antibody, Dmel\\CG6835 antibody, F21A20.90 antibody, F21A20_90 antibody, GLUTATHIONE SYNTHETASE antibody, GSHB antibody, glutathione synthetase 2 antibody, GSHS antibody, AI314904 antibody, GS-A/GS-B antibody, gssls-a antibody, glutathione synthetase antibody, Glutathione Synthetase antibody, glutathione synthetase 2 antibody, glutathione synthetase L homeolog antibody, GSS antibody, GSH2 antibody, Tola_1250 antibody, PC1_3711 antibody, Dd586_3633 antibody, Kvar_0701 antibody, Alvin_0197 antibody, Nhal_0215 antibody, BC1002_0254 antibody, Cseg_4017 antibody, Snov_3844 antibody, Aazo_1904 antibody, M301_2613 antibody, Bresu_0515 antibody, Isop_1460 antibody, Marme_4020 antibody, Thicy_0325 antibody, Sinme_3668 antibody, Mesop_0757 antibody, Gss antibody, gss.L antibody
    背景

    Synonyms: Glutathione synthase; GSH S; GSH synthetase; GSH-S; GSHB_HUMAN; GSHS; GSS antibodyMGC14098; OTTHUMP00000030711.

    Background: GSS (Glutathione synthetase) is a 474 amino acid protein encoded by the gene located at human chromosome 20q11.2. GSS consists of three loops projecting from an antiparallel -sheet, a parallel -sheet and a lid of anti-parallel sheets, which provide access to the ATP-binding site. Although Southern blot and gene analysis suggest that GSS may be the only member of a unique family, the crystal structure indicates that GSS belongs to the ATP-GRASP superfamily. GSS is expressed in hemocytes and nucleated cells, including the brain. GSS occurs as a homodimer. There are two steps in the production of Glutathione, begining with GSS (Glutathione synthetase) is a 474 amino acid protein encoded by the gene located at human chromosome 20q11.2. GSS consists of three loops projecting from an antiparallel -sheet, a parallel -sheet and a lid of anti-parallel sheets, which provide access to the ATP-binding site. Although Southern blot and gene analysis suggest that GSS may be the only member of a unique family, the crystal structure indicates that GSS belongs to the ATP-GRASP superfamily. GSS is expressed in hemocytes and nucleated cells, including the brain. GSS occurs as a homodimer. There are two steps in the production of Glutathione, begining with ©-GCS and ending with GSS. In an ATP-dependent reaction, GSS produces Glutathione from ©-glutamylcysteine and glycine precursors. Partial hepatectomy, diethyl maleate, buthionine sulfoximine, tert-butylhaydroquinone and thioacetamide increase the ex-pression of GSS, which causes an increase in Glutathione levels. An inherited autosomal recessive disorder, 5-oxoprolinuria (pyroglutamic aciduria), is caused by GSS deficiencies, which leads to central nervous system damage, hemolytic anemia, metabolic acidosis and urinary excretion of 5-oxoproline. A missense mutation in the gene encoding GSS leads to a GSS deficiency restricted to erythrocytes, which causes only hemolytic anemia.-GCS and ending with GSS.

    途径
    Warburg Effect
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